Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation

Phase 4

Completed

• Conditions: Acute Asthma
• Interventions: Device: Continuous positive airway pressure

• Registration Number: NCT01403467
• Lead Sponsor: Ramathibodi Hospital

Brief Summary

This current study aimed to demonstrate the effectiveness of the addition of CPAP to the current conventional therapy in terms of airway obstruction improvement in acute asthma patients.

Detailed Description

Continuous positive airway pressure (CPAP) is widely used in providing ventilator support. However, its role in an acute asthmatic attack is uncertain. The purpose of this study was to compare the efficacy of CPAP when used in addition to conventional therapy with conventional therapy alone in the management of acute asthma exacerbation.

Study Timeline

• Study Start: 2009-04
• Primary Completion: 2010-01
• Status Verified: 2010-12
• Study Completion: 2011-01
• Study First Submitted: 2011-07-25
• Study First Submitted QC: 2011-07-26
• Last Update Submitted: 2011-07-26
• Study First Posted: 2011-07-27
• Last Update Posted: 2011-07-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 86

Inclusion Criteria

• aged over 18 years
• known asthmatic patients visiting ED with acute exacerbation
• had given their written informed consent.

Exclusion Criteria

• smoking history
• chronic obstructive pulmonary disease
• required intubation
• instability of hemodynamic or arrhythmia
• unable to perform PEFR
• facial abnormality
• pulmonary infiltration
• pregnancy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
NIPPV	Continuous positive airway pressure	-

Primary Outcome Measures

Name	Time	Method
an improvement in PEFR, as % predicted	75 mins

Trial Locations

Locations (1)

Ramathibodi Hospital; 🇹🇭 Bangkok, Thailand