Investigation of the effect of InterLeukin-1 receptor Antagonist on markers of inflammation in non-ST elevation acute coronary syndromes

niversity of Sheffield (UK)0 个研究点目标入组 186 人开始时间: 2006年10月3日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Aged over 18 years of age
•2. Acute severe cardiac chest pain consistent with an acute coronary syndrome
•3. Less than 48 hours from onset of symptoms that led to hospital admissions
•4. And at least one of the following:
•a. Horizontal or down-sloping ST depression of at least 0.5mm in at least two Electrocardiogram (ECG) leads
•b. a raised troponin as defined by local parameters specified at each centre
•c. Other ECG changes consistent with acute myocardial ischaemia (e.g. T-wave inversion of at least 3 mm, in at least two leads of the ECG, or new onset bundle branch block) and an elevated level of Troponin above local laboratory values indicating myocardial damage

•1. Less than 18 years of age
•2. Persistent ST elevation on the presenting ECG
•3. Intention to treat with an urgent reperfusion strategy (thrombolysis or primary percutaneous coronary intervention)
•4. Percutaneous coronary intervention within previous three months
•5. Previous coronary artery bypass grafting
•6. ECG showing paced rhythm
•7. Cardiogenic shock (as defined in the Trial Manual)
•8. Any serious co-morbidity which makes it unlikely that the patient will complete trial procedures and follow-up
•9. Treatment or under active follow-up for rheumatoid arthritis, other connective tissue diseases or inflammatory bowel disease
•10. End stage renal disease or a Creatinine more than 220 µmol/L
•11. Pregnancy or suspected pregnancy (any potential female participant of child bearing age will need a negative pregnancy test prior to study entry)
•12. Eosinophilia
•13. Anti-Tumour Necrotising Factor (TNF) biologies
•14. Active infection
•15. Malignancy

发起方

niversity of Sheffield (UK)