NCT02847533Unknown不适用
Inflammatory Markers and Resistant Depression
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 108
- 试验地点
- 2
- 主要终点
- plasmatic concentration of Interleukin 6
研究概览
简要总结
This study focuses on blood inflammatory markers (pro-inflammatory cytokines, anti-inflammatory cytokines, monocytes costimulation molecules) in patients with resistant unipolar depression in comparison with non-resistant unipolar depressed patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Factorial
- 主要目的
- Screening
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •group 1: Patients with resistant MDD (at least 2 failed treatments for the current episode) ,current treatment with IRS or IRSNA,
- •group 2: patients with MDD remission after response to an antidepressant treatment.
排除标准
- •comorbid somatic or psychiatric disorders: chronic or acute inflammatory diseases, previous treatment with brain stimulation for the current episode, legal protection
结局指标
主要结局
plasmatic concentration of Interleukin 6
时间窗: at patient inclusion
次要结局
- concentration of proinflammatory cytokine(at patient inclusion)
- concentration of antiinflammatory cytokine(at patient inclusion)
- plasmatic concentration of Retinoid X receptor signaling pathway(at patient inclusion)
- Expression rate of monocytes costimulation molecules(at patient inclusion)
- functional polymorphisms of expression genes of inflammatory proteins(at patient inclusion)
研究者
研究点 (2)
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