NL-OMON38316
Completed
N/A
A study to evaluate the response of whole blood stimulation with lipopolysaccharide or other inducers and its in vitro inhibition in healthy volunteers, and patients with a chronic inflammatory condition - LPS-pilot healthy volunteers/patients
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- atherosclerose
- Sponsor
- Centre for Human Drug Research
- Enrollment
- 250
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •healthy males
- •healthy female volunteers: pre\- and post\-menopausal
- •patients with rheumatoid arthritis: active disease and with or without treatment with MTX
- •patients with Crohn's disease: clinically confirmed diagnosis of disease
- •patients with psoriasis: clinically confirmed diagnosis of disease, PASI score\>5
- •patients with asthma: clinically confirmed diagnosis of disease
- •patients with proven atherosclerotic disease
Exclusion Criteria
- •general: any clinically significant disorder (current or past medical history or physical examination) that in the opinion of the investigator precludes study participation
- •patients: clinically significant abnormalities and recent treatment with anti\-TNF therapy
Outcomes
Primary Outcomes
Not specified
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