A study to evaluate the response of whole blood stimulation with lipopolysaccharide or other inducers and its in vitro inhibition in healthy volunteers, and patients with a chronic inflammatory conditio
Completed
- Conditions
- atheroscleroserheumatoid arthritis100110821000321610003816
- Registration Number
- NL-OMON38316
- Lead Sponsor
- Centre for Human Drug Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 250
Inclusion Criteria
healthy males
healthy female volunteers: pre- and post-menopausal
patients with rheumatoid arthritis: active disease and with or without treatment with MTX
patients with Crohn's disease: clinically confirmed diagnosis of disease
patients with psoriasis: clinically confirmed diagnosis of disease, PASI score>5
patients with asthma: clinically confirmed diagnosis of disease
patients with proven atherosclerotic disease
Exclusion Criteria
general: any clinically significant disorder (current or past medical history or physical examination) that in the opinion of the investigator precludes study participation
patients: clinically significant abnormalities and recent treatment with anti-TNF therapy
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>activation markers of inflammation (cytokines, chemokines, etc)</p><br>
- Secondary Outcome Measures
Name Time Method <p>n/a</p><br>