Biodiversity Interventions for Well-being, Neighborhood Rewilding
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Skin Gammaproteobacteria
研究概览
简要总结
Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities, which weakens the functionality of the urban ecosystems and the well-being of citizens. This may also increase the risk of immune-mediated disorders among urban dwellers.
In Biodiversity interventions for well-being (BIWE), microbial biodiversity interventions are performed to increase biodiversity in urban built areas. Results from the intervention trials are combined with publicly available land cover and ecological data. These are analyzed from the viewpoint of shifts in ecosystems and human well-being and immune regulation, ecological quality, and urban planning.
The investigators set up an intervention study in which urban private yards are rewilded with diverse vegetation and decaying deadwood and plant residuals. The investigators aim to evaluate the effect of rewilding, and yard management practices on commensal microbiome, cortisol levels and well-being and salivary cytokine levels, and gene pathways.
详细描述
Our specific aims are:
To assess if rewilding diversifies health-associated skin microbiota and is associated with salivary cytokine levels, gene pathways, cortisol levels and commensal microbiota.
Assess whether there are patterns in the microbiome associated with the salivary cytokine levels and hair cortisol levels.
Assess whether rewilding affects health and psychological measures, such as Perceived Stress Scale (PSS), Warwick-Edinburgh Mental Wellbeing Scale (SWEMWS), Depression Scale (DEPS) and Nature Relatedness Scale (NR6).
The investigators will recruit approximately 42 (21 study subjects per treatment) subjects living in a detached house or terraced house in urban areas and aged between 18-72.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
The research subjects were not randomized or masked to the intervention and control group, because the control group needs volunteers who have no intention of following the yard management instructions advised to the intervention group.
入排标准
- 年龄范围
- 18 Years 至 72 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Living in a detached or terraced house in urban area
排除标准
- •Immunosuppressive medications
- •Immune deficiencies
- •a disease affecting immune response (e.g., colitis ulcerosa, rheumatoid arthritis, Crohn's disease, diabetes)
- •cancer diagnosis within the last year or on-going cancer treatment
- •Incompetency
- •Living outside city area.
结局指标
主要结局
Skin Gammaproteobacteria
时间窗: Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year
Difference on skin gammaproteobacterial diversity between rewilding and control group
次要结局
- Cortisol levels(Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year)
- Salivary cytokines(Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year)
- Difference in taxonomies of skin, saliva and stool microbiota(Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year)
- Difference in microbial gene pathways of saliva and stool microbiota(Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year)
- Perceived Stress Scale(Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year)
- Nature Relatedness Scale(Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year)
- Difference in diversity (Alpha and beta diversity) of skin, saliva and stool microbiota(Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year)
- Difference in observed species richness of skin, saliva and stool microbiota(Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year)
- Metabolites in urine(Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year)
- Warwick-Edinburgh Mental Wellbeing Scale(Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year)
- Depression Scale(Baseline, 3 month, 1 year, 2 year, 3 year, 4 year, 5 year)