Qing-Xin Jie-Yu Granules on cardiopulmonary function for patients with heart failure with preserved ejection fraction: a randomized controlled trial
- Conditions
- heart failure with preserved ejection fraction
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. Both genders aged 40-70 years;
2. Patients with chronic heart failure, NYHA II-III,can complete cardiopulmonary exercise test, whose medications had not been adjusted whthin 2 weeks;
3. LVEF >= 50%;
4. NT-proBNP >= 400pg/mL;
5. Patients signed the written informed consent.
1. LVEF < 50% at any time in the past;
2. Solely right heart failure due to lung disease;
3. Short breath caused by non-cardiac diseases, such as lung disease, anemia, severe obesity, primary valvular heart disease, and cardiomyopathy;
4. Patients with cardio-cerebrovascular disease are planed to undertake revascularization therapy in three months;
5. Patients with serious primary diseases, such as liver, kidney and hematopoietic system, psychosis and severe neurosis;
6. Patients with uncontrolled hypertension(systolic pressure >= 160mmhg, or diastolic pressure >= 100mmhg);
7. Recent recurrence of malignant arrhythmia (paroxysmal ventricular tachycardia);
8. Pregnant, planned pregnant or lactating women
9. Those who participated in other clinical trials in the past 1 month;
10. Allergic constitution or allergy to known ingredients of the test drug.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Maximum oxygen uptake;
- Secondary Outcome Measures
Name Time Method 6-minute walk test;Minnesota Heart Failure Quality of life scale;Hs-CRP;Cardiac diastolic function;NT-pro BNP;