Comparison of Changes in Neuromuscular and Functional Performance Due to Resistance Training With Low-Load or High-Load in Persons With Parkinson's Disease.
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- University of Miami
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Change in neuromuscular performance as measured by 1-repetition maximum (1RM)
Overview
Brief Summary
This study will compare the effects of high-load resistance training to low-load resistance training, on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 50 Years to 85 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Parkinson's Disease Hoehn \& Yahr Stages 1-3
- •Able to walk 50m unassisted
- •Able to understand and communicate in English
- •A Montreal Cognitive Assessment (MoCA) score above 18
Exclusion Criteria
- •Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
- •Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
- •Unresolved injury or surgery to the upper or lower limbs that prevents weight training.
Arms & Interventions
Low-Load Resistance Training
Participants will receive low-load resistance training, twice per week for at least 24 sessions for up to 12 weeks.
Intervention: Low-Load Resistance Training (Behavioral)
High-Load Resistance Training
Participants will receive high-load resistance training, twice per week for at least 24 sessions for up to 12 weeks.
Intervention: High-Load Resistance Training (Behavioral)
Outcomes
Primary Outcomes
Change in neuromuscular performance as measured by 1-repetition maximum (1RM)
Time Frame: [Time Frame: Baseline, 12 weeks]
Maximal load that can be lifted in one repetition (1RM) will be assessed in both leg press and chest press exercises. The loads on the testing equipment will be increased across 5 to 7 testing repetitions. The persons 1RM will be the highest load the person can move through the range of motion of the exercise. There are no minimum or maximum scores for this test. The higher the 1RM the stronger the person is. The unit of measurement is kilograms.
Change in neuromuscular performance as measured by Power Production
Time Frame: Baseline, 12 weeks
This test measures the power a person can produce at maximal speed using loads of 20%, 40%, 60%, 80%, and 90% of 1RM for the chest press and leg press. Power shows how fast a person can do work. Unit of measure is Watts.
Secondary Outcomes
- Change in the Speed of the Ten-Meter Walk Test.(Baseline, 12 weeks)
- Change in Time for the Five Times Sit-to-Stand Test.(Baseline, 12 weeks)
- Change in the time required to complete the timed Up-and-Go Test.(Baseline, 12 weeks)
- Change in Distance of the Seated Medicine Ball Throw.(Baseline, 12 weeks)
Investigators
Joseph Signorile
Professor
University of Miami