NCT05119413已完成2 期
Comparison of a New Masterful Preparation to Kligman's Trio in the Treatment of Melasma: a Double Blind Prospective Randomzed Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- The melasma's type
研究概览
简要总结
Kligman's trio remains the gold standard treatment for melasma. It contain hydroquinone which is an effective anti-melanogenic compound but that has poor tolerance and numerous side-effects. Thiamidol has been proven to be at least as effective as hydroquinone and has a very good safety profile. The objective of this study is to compare the Kligman's trio to the same preparation in which hydroquinone is replaced by thiamidol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •SIGNED WRITTEN CONSENT 1) Melasma clinically diagnosed
排除标准
- •Pregnant woman
- •Other pigmentary disorder affecting the face
- •Use of systemic or topical steroids or retinoids, use of topical depigmenting agents or depigmenting procedure in the month before the inclusion
研究组 & 干预措施
New traitement
Experimental
Thiamidol, retinoid, topical steroid preparation
干预措施: New trio de Kligman (Drug)
Kligman's trio
Other
Application once a day for 12 weeks
干预措施: Trio Kligman (Drug)
结局指标
主要结局
The melasma's type
时间窗: at 12 weeks
Clinical score MASI
次要结局
- the Quality of life of patient(at 12 weeks)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
3 期
Efficacy and Safety of a 4% Hydroquinone Cream for the Treatment of MelasmaFacial MelasmaNCT02095990Mesoestetic Pharma Group S.L.17
终止
4 期
Treatment of Melasma With Stabilized Kligman Preparation Associated or Not With Pulsed Dye LaserMelanosisNCT00863278Centre Hospitalier Universitaire de Nice20
已完成
1 期
Efficacy determination on anti-melasma and whitening product of Mazaru whitening and anti-melasma creamHealthy Thai female subjects aged between 25ᇁ yearTCTR20200622004Innofocus Company Limited33
招募中
早期 1 期
Curcuma Xanthorriza Roxb. 10% Cream for MelasmaMelasmaNCT06153134Universitas Padjadjaran15
进行中（未招募）
Unknown
Kojic Acid Serum and Microneedling in the treatment of MelasmaMelanoseC17.800.621.430RBR-7kxf2k4Faculdade de Farmácia da Universidade Federal do Rio de Janeiro