Effect of Ascorbic Acid Final Flush on Post-operative Pain in Mandibular Molars.

Not Applicable

• Conditions: Post Operative Pain
• Interventions: Drug: Ascorbic acid; Other: saline

• Registration Number: NCT05478044
• Lead Sponsor: Cairo University

Brief Summary

The study is conducted to evaluate the effect of Ascorbic acid as a final flush on post operative pain after single visit root canal treatment in cases with symptomatic irreversible pulpits.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-07
• Study First Submitted: 2022-07-24
• Study First Submitted QC: 2022-07-26
• Last Update Submitted: 2022-07-27
• Study First Posted: 2022-07-28
• Study Start: 2022-08
• Last Update Posted: 2022-08-01
• Primary Completion: 2023-08
• Study Completion: 2023-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients above 18 years old and to 60.
• Male or female.
• Patients seeking root canal treatment.
• mandibular molar teeth with symptomatic irreversible pulpits with preoperative acute or moderate pain with hot and cold stimulation with normal periapical radiographic appearance .
• healthy patient (ASA I,II).
• Patient who can understand NRS and sign informed consent.

Exclusion Criteria

• Medically compromised patients having significant systemic disorders. (ASA III or IV).
• History of intolerance to NSAIDS.
• External root resorption.
• Internal root resorption.
• Vertical root fracture.
• Periapical lesion.
• Pregnancy.
• Use of ibuprofen in the last 12 hour.
• Bleeding disorder.
• Long term corticosteroid use.
• Mobility Grade II or III.
• Pocket depth more than 5mm.
• Previous root canal therapy.
• Non-restorability.
• TMJ problems, bruxism, clenching or traumatic occlusion.
• Inability to perceive the given instructions.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ascorbic acid	Ascorbic acid	Ascorbic acid IV ampoules 20% as a final flush irrigation 3ml after cleaning and shaping.
Saline	saline	A mixture of sodium chloride and water (0.9%) as a final flush irrigation 3 ml after cleaning and shaping.

Primary Outcome Measures

Name	Time	Method
Pain intensity measured by numerical rating scale where 0= no pain, 1-3= mild pain, 4-6= moderate pain and 7-10= severe pain.	up to 48 hours after root canal treatment.

Secondary Outcome Measures

Name	Time	Method
If there are analgesics taken by the patient after root canal treatment and that will be measured by a questionnaire.	up to 48 hours.