NCT05478044Unknown不适用
Effect of Ascorbic Acid as a Final Flush on Post-operative Pain After Single Visit Root Canal Treatment for Patients With Symptomatic Irreversible Pulpits Related to Mandibular Molars: Randomized Controlled Trial.
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- Pain intensity measured by numerical rating scale where 0= no pain, 1-3= mild pain, 4-6= moderate pain and 7-10= severe pain.
研究概览
简要总结
The study is conducted to evaluate the effect of Ascorbic acid as a final flush on post operative pain after single visit root canal treatment in cases with symptomatic irreversible pulpits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients above 18 years old and to
- •Male or female.
- •Patients seeking root canal treatment.
- •mandibular molar teeth with symptomatic irreversible pulpits with preoperative acute or moderate pain with hot and cold stimulation with normal periapical radiographic appearance .
- •healthy patient (ASA I,II).
- •Patient who can understand NRS and sign informed consent.
排除标准
- •Medically compromised patients having significant systemic disorders. (ASA III or IV).
- •History of intolerance to NSAIDS.
- •External root resorption.
- •Internal root resorption.
- •Vertical root fracture.
- •Periapical lesion.
- •Pregnancy.
- •Use of ibuprofen in the last 12 hour.
- •Bleeding disorder.
- •Long term corticosteroid use.
- •Mobility Grade II or III.
- •Pocket depth more than 5mm.
- •Previous root canal therapy.
- •Non-restorability.
- •TMJ problems, bruxism, clenching or traumatic occlusion.
- •Inability to perceive the given instructions.
研究组 & 干预措施
Ascorbic acid
Experimental
Ascorbic acid IV ampoules 20% as a final flush irrigation 3ml after cleaning and shaping.
干预措施: Ascorbic acid (Drug)
Saline
Placebo Comparator
A mixture of sodium chloride and water (0.9%) as a final flush irrigation 3 ml after cleaning and shaping.
干预措施: saline (Other)
结局指标
主要结局
Pain intensity measured by numerical rating scale where 0= no pain, 1-3= mild pain, 4-6= moderate pain and 7-10= severe pain.
时间窗: up to 48 hours after root canal treatment.
次要结局
- If there are analgesics taken by the patient after root canal treatment and that will be measured by a questionnaire.(up to 48 hours.)
研究者
Kariman Mohammed Mohammed Amin Ismaiel
Research assistant of endodontics
Cairo University
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