A prospective randomized controlled trial for Yan's Jiangzhi Decoction Combined with atorvastatin in the treatment of dyslipidemia complicated with carotid atherosclerosis

Phase 1

• Conditions: dyslipidemia; carotid atherosclerosis

• Registration Number: ITMCTR2000003687
• Lead Sponsor: Shanghai Tenth People's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. According to the diagnosis of dyslipidemia with carotid atherosclerosis and / or plaque;
2. TCM syndrome differentiation belongs to Spleen Qi weakness, phlegm and blood stasis block;
3. Aged 18-70 years;
4. Although taking lipid-lowering drugs, the drug has been stopped for more than 2 weeks, and the blood lipid level still reaches the rising standard;
5. Patients are informed and sign informed consent voluntarily.

Exclusion Criteria

1. Familial hyperlipidemia;
2. Simple decrease of HDL;
3. Secondary hyperlipidemia caused by drugs or other diseases;
4. Unstable angina pectoris, acute myocardial infarction, cerebrovascular accident, or PCI in recent three months;
5. Patients with heart failure and cardiac function NYHA >= class III; complicated with severe arrhythmia (such as frequent premature ventricular contractions, ventricular tachycardia, fast atrial fibrillation, etc.);
6. Uncontrolled grade 3 hypertension;
7. Body mass index (BMI)> 31;
8. Heparin, thyroxine and other drugs affecting blood lipid metabolism are being used;
9. Serious or unstable heart, liver, kidney, endocrine, blood and other medical diseases;
10. Mental illness or alcohol, drug dependence, cancer, diabetes;
11. Moderate and severe liver damage, moderate and severe abnormal liver function;
12. Allergic constitution, lactation, pregnant women, plan to get pregnant during the trial or to make their spouse pregnant;
13. Participated in other clinical trials within 3 months.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
blood fat;

Secondary Outcome Measures

Name	Time	Method
Carotid ultrasound;High density lipoprotein;total cholesterol;triglyceride;