NCT01734356终止不适用
Molecular Mechanism Identification in Inherited Arrhythmias and Valvulopathies From Induced Pluripotent Stem Cells
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Production of cardiomyocytes modele from skin fibroblast of arrhythmic patient
研究概览
简要总结
The recent developments of research on iPS (induced pluripotent stem) cells lead to the establishment of mature cell lines such as cardiomyocytes or valvular interstitial cells with genetic and cellular characteristics of the donors. These cells represent a biological material more readily available to identify the pathophysiological mechanisms involved in the diseases of BrS or ERS patients, which will lead to the identification of genetic markers.
研究设计
- 研究类型
- Interventional
- 盲法
- None
入排标准
- 年龄范围
- 22 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient with a family history of inherited arrhythmia or valvulopathy
- •Age : 22-60 yo.
- •patient no confine to bed
- •Male or female
- •Written consent
- •Patient affiliated to the French social security
排除标准
- •Pregnant woman
- •Patient under 22 yo or adults under guardianship
- •Indication against local anesthesia
- •Anticoagulant treatment
- •Absence or positivity of HIV, HBV, HCV serology
研究组 & 干预措施
inherited arrhythmias
Other
6 patient with inherited arrhythmias
干预措施: Skin biopsies (Other)
valvulopathies
Other
6 patient with valvulopathies
干预措施: Skin biopsies (Other)
controle
Other
8 healthy people for these pathologies
干预措施: Skin biopsies (Other)
结局指标
主要结局
Production of cardiomyocytes modele from skin fibroblast of arrhythmic patient
次要结局
- Production of valve interstitial cells modele from skin fibroblast of patient with a valvulopathy
研究者
研究点 (1)
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