Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 95
- 试验地点
- 4
- 主要终点
- memory lapse rate at 24 hours in the severe group, the benign group and the control group. ("memory lapse rate": rate of non recalled words number, during the delayed recall phase of the test, related to the maximal number of words recalled
研究概览
简要总结
Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information.
Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group.
Primary purpose:
To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the "severe group", compared to the "benign group" and the control group.
Secondary purposes:
- to study the evolution over time of memory consolidation
- to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 13 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •normal psychomotor development
- •informed consent signed by both parents and subject if able
- •affiliated to social security regimen
- •Patients from "severe" and "benign" groups:
- •focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria)
- •children hospitalized for their follow-up
- •normal neuroimaging
- •Control group
- •children hospitalized for a non neurologic disease
排除标准
- •Psychiatric trouble (DSM V) Sensorial trouble without correction Poor command of French language Minor under care
- •Patients from "severe" and "benign" groups:
- •degenerative disease
- •abnormal neuroimaging
- •mental deficiency
- •Control group
- •neurologic trouble
- •abnormal sleep EEG
- •intellectual deficiency
结局指标
主要结局
memory lapse rate at 24 hours in the severe group, the benign group and the control group. ("memory lapse rate": rate of non recalled words number, during the delayed recall phase of the test, related to the maximal number of words recalled
时间窗: 24 hours
次要结局
- Correlation of memory lapse rate with EEG severity scale, atypical criteria, EEG focus localization, sleep discharges frequency(at 1 hour, 5 hours, 24 hours)
- Correlation of memory lapse rate with Executive functioning tests scores(at 1 hour, 5 hours, 24 hours)
- Correlation of memory lapse rate with age of onset, epilepsy phase, treatment(at 1 hour, 5 hours, 24 hours)
- memory lapse rate for each group(at 1 hour, 5 hours, 24 hours)
- Correlation of memory lapse rate with number and organization of sleep cycles(at 1 hour, 5 hours, 24 hours)