NCT06346041招募中早期 1 期
A Phase I Study of Evaluating the Safety and Efficacy of Intravenous IDOV-SAFETM in Patients With Advanced Solid Tumors
Cancer Institute and Hospital, Chinese Academy of Medical Sciences1 个研究点 分布在 1 个国家目标入组 19 人开始时间: 2024年4月12日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 早期 1 期
- 状态
- 招募中
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Incidence of adverse events and severe adverse events
研究概览
简要总结
This is an open-label, dose escalation, phase I study to evaluate safety tolerability, MTD or MFD, pharmacokinetic profile, immunogenicity, and pharmacodynamic profile of IDOV-SAFETM in patients with advanced solid tumors.
详细描述
The study is a single agent dose escalation which will use an accelerated and "3+3" design to evaluate escalating doses of IDOV-SAFETM.Total enrollment will depend on the toxicities and/or activity observed, with approximately 13-19 evaluable participants enrolled. A Dose-Limiting Toxicity (DLT) observation period of 3weeks was established before the entry of the first patient at the next dose level. After all subjects in the current dose group have completed the DLT observation period, the administration of the next dose group can only be started if the condition of dose escalation is met.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Understand and voluntarily sign a written informed consent;
- •Male and female, ≥18 years old and ≤75 years old;
- •Histologically or cytologically confirmed advanced malignant solid tumors that do not respond to standard treatment (disease progression or treatment intolerance after treatment) or currently lack effective standard treatment (including but not limited to advanced MSS colorectal cancer);
- •ECOG physical status score 0~1;
- •Expected survival ≥3 months;
- •At least one evaluable lesion according to the solid tumor response criteria (RECIST version 1.1). Note: If the only evaluable disease site has previously received radiation therapy, it can be considered an evaluable lesion after determining disease progression;
- •Major organ and bone marrow functions meet the following criteria within 7 days prior to initial dosing:
- •Blood routine: neutrophils ≥1.5×109/L, platelets > 100×109/L, hemoglobin ≥90g/L(no blood transfusion, no supportive treatment with G-CSF and other drugs within 2 weeks before screening);
- •Liver function: General patients: alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST)≤3× upper limit of normal; Total bilirubin ≤1.5× upper limit of normal value; Patients with liver metastasis: ALT and/or AST ≤5× upper limit of normal;
- •Renal function: serum creatinine (Cr)≤1.5× upper limit of normal value or creatinine clearance CCr≥60ml/min(using Cockcroft-Gault formula: The Ccr (ml/min) = [(140 - age) * weight kg * F] / [serum creatinine (mg/dl) x 72] (F = 1 male, the female F = 0.85).
- •Coagulation function: prothrombin time (PT)≤ 1.5×ULN or International Normalized ratio (INR)≤ 1.5×ULN, and activated partial thromboplastin time (APTT)≤ 1.5×ULN;
- •The blood pregnancy results of fertile female subjects within 7 days prior to the first dosing must be negative. Female subjects were willing to use highly effective contraception during the trial and for at least 90 days after the last dose of the trial drug. Male subjects were willing to use highly effective contraception during the trial and for at least 90 days after the last dose of the trial drug.
排除标准
- •Severe systemic reactions or side effects due to prior smallpox vaccination;
- •Patients with known to be allergic to the test drug or its excipients;
- •Patients with a history of other tumors within 5 years prior to screening, excluding effectively resected cervical carcinoma in situ, low-risk gastrointestinal stromal tumor, breast cancer, cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma, and papillary thyroid carcinoma;
- •Patients with untreated symptomatic central nervous system metastases (CNS) who meet one of the following criteria can be enrolled:
- •CNS metastasis is asymptomatic and does not require treatment;
- •The CNS metastases have been treated, neurological symptoms have returned to baseline (except for treatment-related residual signs or symptoms), glucocorticoids have been discontinued for at least 2 weeks prior to randomization, and imaging studies within 28 days prior to randomization suggest that the CNS lesions are radiographically stable.
- •Pial metastasis;
- •Subjects with uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage;
- •Previous acceptance of oncolytic viruses, stem cells or gene therapy products;
- •Patients with received systemic antitumor therapy, including but not limited to chemotherapy, endocrine therapy, and immunotherapy, within 4 weeks before the first dose; Oral small-molecule targeted drugs are administered 2 weeks before the first dose or within 5 half-lives of the drug (whichever is longer); Palliative radiotherapy within 14 days before the first dose; Participated in clinical trials of other antitumor drugs within 4 weeks; Received any Chinese herbal medicine or proprietary Chinese medicine for any anti-tumor indication within 2 weeks prior to initial administration;
- •The adverse reactions of previous anti-tumor therapy have not returned to CTCAE 5.0 grade evaluation ≤ Class 1 (except toxicity judged by the investigator to have no safety risk);
- •Patients with received surgery or interventional treatment (excluding tumor biopsy, puncture, etc.) or unhealed wounds, ulcers or fractures within 4 weeks prior to the first dose;
- •Patients with a history of severe cardiovascular and cerebrovascular disease, including but not limited to: congestive heart failure ≥ Class II of the New York Heart Association (NYHA); Left ventricular ejection fraction (LVEF)<50%; QT interval (QTcF)>470ms as corrected by the Fridericia method or prolonged QT interval syndrome; Acute coronary syndrome, aortic dissection, severe arrhythmia, stroke, or other grade 3 or higher cardiovascular and cerebrovascular events occurred within 6 months before the first treatment; Hypertension poorly controlled by standard treatment (systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg);
- •Patients with a history of exfoliated skin that requires systemic treatment (such as eczema or ectopic dermatitis);
- •Active hepatitis B (HbsAg positive, HBV DNA test value greater than the upper limit of normal); Active hepatitis C (those with positive anti-HCV antibodies are further tested positive for HCV RNA); A known history of immunodeficiency virus (HIV) disease or a positive HIV antibody test;
- •Subject with an active infection or developed an unexplained fever > 38.5 ° C during screening or prior to initial administration;
- •There is evidence of clinically significant immunodeficiency, such as a primary immunodeficiency state, such as severe combined immunodeficiency disease (SCID); Co-opportunistic infection;
- •At the time of screening, patients with active autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, vasculitis, etc., or with a history of autoimmune diseases that may recur, except for the following conditions: (1)Type 1 diabetes; (2)Hypothyroidism (if controlled with hormone replacement therapy alone); (3)Controlled celiac disease; (4)Skin diseases that do not require systemic treatment;(5) Any other disease that will not recur in the absence of an external trigger;
- •Subject with an active infection or developed an unexplained fever > 38.5 ° C during screening or prior to initial administration;are receiving long-term systemic steroid (prednisone >10mg/ day or equivalent dose of the same drug) or any other form of immunosuppressant therapy within 14 days prior to initial treatment; Treatment with topical, ocular, intra-articular, intranasal, and inhalation corticosteroids is excluded; Short-term use of corticosteroids (≤10mg equivalent dose of prednisone) for preventive treatment (e.g. prevention of contrast agent allergy);
- •Patients with received allogeneic tissue or solid organ transplantation;
- •Other diseases or abnormalities assessed by the investigator as unsuitable for participation in the study.
研究组 & 干预措施
Oncolytic Virus injection(IDOV-SAFETM)
Experimental
Intravenous administration of IDOV-SAFETM as single agent for patients with advanced solid tumors.
Dose cohorts: 1x10^9 pfu、3x10^9 pfu、1x10^10 pfu and 3x10^10 pfu
干预措施: Oncolytic Virus injection(IDOV-SAFETM) (Biological)
结局指标
主要结局
Incidence of adverse events and severe adverse events
时间窗: Within day 85 after administration
Graded according to the NCI CTCAE version 5.0
Dose Limiting Toxicities (DLT)
时间窗: Within day 21 after administration
Dose-limiting toxicity is defined as an adverse event that is considered to be drug-related and meets one of the Protocol definitions
MTD/MFD
时间窗: Within day 21 after administration
To explore the maximum tolerated dose (MTD) or maximum administration dose (MFD) of IDOV-SAFETM in patients with advanced solid tumors.
次要结局
- Immunogenicity of IDOV-SAFETM(Up to 85 days)
- DCR(Every 6 weeks (±7 days) after initial administration and every 12 weeks (±7 days) after 1 year)
- PFS(Every 6 weeks (±7 days) after initial administration and every 12 weeks (±7 days) after 1 year)
- The Pharmacokinetics characteristics of IDOV-SAFETM((biological distribution and viral expulsion))(Up to 2 days)
- ORR(Every 6 weeks (±7 days) after initial administration and every 12 weeks (±7 days) after 1 year)
- DOR(Every 6 weeks (±7 days) after initial administration and every 12 weeks (±7 days) after 1 year)
- OS(Up to death)
研究者
研究点 (1)
Loading locations...
相似试验
尚未招募
1 期
Study on the Safety and Efficacy of Intratumoral Administration of IDOV-SAFETM in the Treatment of Advanced Solid TumorsAdvanced Malignant Solid TumorNCT06713148Fudan University42
招募中
1 期
Study on the Safety and Efficacy of Intravenous Administration of IDOV-SAFETM in the Treatment of Advanced Solid TumorsNCT06718946Fudan University38
进行中（未招募）
1 期
A Study of FDA018-ADC in Patients With Advanced Solid TumorsAdvanced/ Metastatic Solid TumorsNCT05174637Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.78
Unknown
1 期
NOV120401 (CKD-516 Tablet) for Advanced Solid TumorsAdvanced Refractory Solid TumorsNCT02300467National OncoVenture30
已完成
1 期
The Recombinant Humanized Anti-TIGIT Monoclonal Antibody (JS006) Monotherapy and in Combination With Toripalimab in Patients With Advanced TumorAdvanced TumorsNCT05061628Shanghai Junshi Bioscience Co., Ltd.47