Feasibility study for a novel and clinically useful MRI sequence for imaging myelin in MS patients

Completed

• Conditions: loss coordination; multiple sclerosis; 10012303

• Registration Number: NL-OMON41522
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

* Clinically definite MS (according to the subgroups)
* Age between 18 - 60 years of age (to exclude age related chance of other neurological disorders)
* EDSS < 5.5 (despite the fact that especially for SP patients this criterium lowers the number of available volunteers, the physical efforts necessary to complete the protocol may be hard for this group)

Exclusion Criteria

* Clinically isolated syndrome
* Other neurological disorders
* Claustrophobia
* Foreign non MR compatible metal objects in the body
* Foreign metal objects in or close to the head

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p> Highly skilled radiologist from the VUmc will visually compare the standard<br /><br>diagnostic scans (a T2 weighted fast spin echo and a 3D T1 weighted scan)<br /><br>against the myelin water fraction images. All three types of scans will be<br /><br>compared to determine any additional information the myelin water fraction<br /><br>images may give. The healthy controls will provide a standard to judge the<br /><br>impact of MS on the myelin water fraction images of the patients. Any<br /><br>differences between lesions on the standard diagnostics images and the myelin<br /><br>water images will be tabulated. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N/A</p><br>