Role of Vitamin D Supplementation as an Adjuvant Therapy inTreatment of Helicobacter Pylori in Children
- Conditions
- Helicobacter Pylori Infection
- Interventions
- Drug: Helicobacter pylori triple therapy
- Registration Number
- NCT05879237
- Lead Sponsor
- Minia University
- Brief Summary
To study the efficacy of vitamin D in conjunction with Helicobacter pylori treatment in children in eradication of helicobacter pylori.
- Detailed Description
o study the efficacy of vitamin D in conjunction with Helicobacter pylori treatment in children in eradication of helicobacter pylori.
our study include 2 patient groups:
1. st group included 100 child diagnosed Helicobacter pylori infection by upper gastrointestinal endoscopy and biopsies with pathology, will receive H.pylori eradication treatment and vitamin D as an adjuvant therapy .
2. nd group will also diagnosed Helicobacter pylori infection by upper gastrointestinal endoscopy and biopsies with pathology, will receive H.pylori eradication treatment only.
Helicobacter pylori treatment :
1. amoxcillin on 50 mg/kg/day for 2 weeks
2. clarithromycin 20mg/kg/day for 2 weeks
3. proton pump inhibitor 1mg/kg/day for 1month Vitamin d dose..1000unit /day for 1 month
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 200
- Age:4-18 years children with symptomatic H pylori infection presenting with (epigastric pain, persistent vomiting and hematemesis)diagnosed by upper gastrodeudonoscopy , rapid urease test and histopathologic examination of gastric biopsies from antrum and body of the stomach.
- Patient on vitamine D supplémentation
- Patient who has defect in vitamin D metabolism (chronic renal and hepatic patients, malabsorption syndromes)
- Patients who had received treatment of H.pylori previously .
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Triple therapy only Helicobacter pylori triple therapy Standard triple therapy of H pylori Triple therapy therapy and vitamin D3 Helicobacter pylori triple therapy Vitamin D3 ,1000 unit ,once daily, oral, for 1 month plus the standard triple therapy of H pylori (double antibiotics and proton pump inhibitor) Triple therapy therapy and vitamin D3 Vitamin D3 Vitamin D3 ,1000 unit ,once daily, oral, for 1 month plus the standard triple therapy of H pylori (double antibiotics and proton pump inhibitor)
- Primary Outcome Measures
Name Time Method Role of Vitamin D Supplementation as an Adjuvant Therapy inTreatment of Helicobacter Pylori in Children Six month eradication of h pylori in children
- Secondary Outcome Measures
Name Time Method