The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery

Phase 3

• Conditions: Chronic Sinusitis

• Registration Number: NCT00852410
• Lead Sponsor: University of Toronto

Brief Summary

Obtaining adequate hemostasis is crucial during endoscopic sinus surgery. Submucosal injection of local anaesthetic containing adrenaline has frequently been used to improve surgical milieu. However, injection of adrenaline has potential side effects including tachycardia, hypertension as well as inducing arrhythmia. The aim of this randomized clinical trial is to assess the hemodynamic and hemostatic effects of two different concentrations of adrenaline in local anaesthetic used during endoscopic sinus surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-02-26
• Study First Submitted QC: 2009-02-26
• Study First Posted: 2009-02-27
• Study Start: 2009-03
• Primary Completion: 2010-04
• Study Completion: 2010-04
• Status Verified: 2010-06
• Last Update Submitted: 2010-06-29
• Last Update Posted: 2010-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

• recurrent acute sinusitis, chronic sinusitis, or nasal polyposis

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Exclusion Criteria

• bleeding disorders, under age of 18, history of cardiac disease or on antihypertensive medications

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Reduction of Intraoperative bleeding	during surgery

Secondary Outcome Measures

Name	Time	Method
hemodynamic fluctuation	during surgery

Trial Locations

Locations (1)

University of Toronto; 🇨🇦 Toronto, Ontario, Canada