The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery: Randomized Clinical Trial

University of Toronto2 个研究点分布在 1 个国家目标入组 140 人开始时间: 2009年3月最近更新: 2010年6月30日

适应症

试验速览

阶段: 3 期
发起方: University of Toronto
入组人数: 140
试验地点: 2
主要终点: Reduction of Intraoperative bleeding

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Obtaining adequate hemostasis is crucial during endoscopic sinus surgery. Submucosal injection of local anaesthetic containing adrenaline has frequently been used to improve surgical milieu. However, injection of adrenaline has potential side effects including tachycardia, hypertension as well as inducing arrhythmia. The aim of this randomized clinical trial is to assess the hemodynamic and hemostatic effects of two different concentrations of adrenaline in local anaesthetic used during endoscopic sinus surgery.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Single Group
主要目的: Treatment
盲法: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围: 18 Years 至 80 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•recurrent acute sinusitis, chronic sinusitis, or nasal polyposis

排除标准

•bleeding disorders, under age of 18, history of cardiac disease or on antihypertensive medications

结局指标

主要结局

Reduction of Intraoperative bleeding

时间窗: during surgery

次要结局

hemodynamic fluctuation(during surgery)

研究者

发起方

University of Toronto

申办方类型

Other

研究点 (2)

Loading locations...

相似试验

已完成

4 期

Effects of Adrenaline Infiltration on Surgical Field of View in Endoscopic Sinus SurgeryIntraoperative Bleeding

NCT05867342Stanford University40

Unknown

不适用

Intranasal Injection Versus Topical Administration of Epinephrin During Endoscopic Sinus SurgeryTachycardiaBradycardiaHypertensionHypotensionArrhythmia

NCT01075581Tel-Aviv Sourasky Medical Center50

已完成

1 期

Adrenaline Solution Irrigation and Bleeding During Sinus SurgeryChronic Rhinosinusitis (Diagnosis)

NCT04551703Jordan University of Science and Technology60

Unknown

不适用

Propofol and Magnesium Sulfate Intravenous Infusion During Endoscopic Sinus SurgeryEndoscopic Sinus Surgery

NCT04078659Mansoura University50

Unknown

4 期

Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus SurgeryHemodynamic Instability

NCT02464722Korea University Anam Hospital50