The Effect of Two Dıfferent Intravenous Anesthesıa Technıques on Cognıtıve Functıons ın Spınal Surgery
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 128
- Locations
- 1
- Primary Endpoint
- Post-Operative Cognitive Dysfunction
Study Overview
Brief Summary
The aim of this study is to investigate the effect of these two different intravenous infusion techniques [manuel controlled infusion (MCI) and Target controlled Infusion( TCI)] on POCD. To assess POCD, the Mini Mental State Examination (MMSE ) and the Montreal Cognitive Assessment (MoCA ) will be used. MoCA and MMSE have high sensitivity and specificity for identifying patients with mild cognitive impairment who perform within the normal range. In a study by Meng et al., comparing target-controlled infusion and manual infusion of propofol anesthesia during electroconvulsive therapy, the randomized, controlled trial showed no significant difference in postelectroconvulsive therapy changes in MoCA scores in either group; however, they reported improvement in MoCA scores after 6 electroconvulsive therapy treatments in the MCI group, while deterioration occurred in the TCI group. Researchers found no studies investigating the effects of both infusion methods in spinal surgery and their impact on cognitive function, and they planned to evaluate the effects of the groups in their study.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Turkish language proficiency,
- •age (18-65 years),
- •American Society of Anesthesiologists (ASA) I-III score,
- •elective spinal surgery.
Exclusion Criteria
- •- refusal to participate
- •central nervous system disorders,
- •use of antidepressants or antipsychotic medications,
- •alcohol or drug use,
- •illiteracy.
Arms & Interventions
target-controlled infusion group
infusion via microprocessor-controlled infusion pumps operating according to pharmacokinetic algorithms (target-controlled infusion, TCI).
Intervention: Manuel controlled infusion group (Device)
Outcomes
Primary Outcomes
Post-Operative Cognitive Dysfunction
Time Frame: preoperatively and 24 hours postoperatively at the patient's bedside
Montreal Cognitive Assessment (MoCA) scores Normally accepted threshold values: A score of 26 or higher on the MoCA (Montreal Cognitive Assessment) test For cognitive impairment: A decrease of at least 1-2 points on the MoCA is considered significant.
Secondary Outcomes
- Evaluation of intraoperative anaesthezic consumption(intraoperatıve)
Investigators
sermın emınoglu
ASSOCIATE PROFESSOR
Bursa Yuksek Ihtisas Training and Research Hospital