Prevalence of H.Pylori in Patients With Acne Vulgaris Acne Vulgaris

Completed

• Conditions: Acne Vulgaris; Helicobacter Pylori Infection
• Interventions: Other: Blood and stool samples collection

• Registration Number: NCT03411733
• Lead Sponsor: Sohag University

Brief Summary

The objective of the study is to investigate prevalence of H.Pylori infection among acne vulgaris patients.

Detailed Description

The study included patients with acne vulgaris and healthy control participants. The study recruited both sexes, all grades of acne, adolescents and young adults.

All patients were subjected to complete history, general and skin examination Acne vlugaris Patients were classified into mild, moderate and severe according to the classification of American Academy of dermatology for acne vulgaris.

Detection of H. pylori infection:

Blood and stool samples were taken from each participant and was directly transferred to laboratory for detection of H. Pylori antigen and antibody.

An enzyme-linked immune sorbent assay (ELISA) was used for quantitative assessment of IgG antibodies against H.Pylori in human serum.

A monoclonal antibodies based enzyme-linked immunosorbent assay was used to detect H.Pylori specific antigen in stool samples.

Study Timeline

• Study Start: 2017-03-01
• Study First Submitted: 2018-01-20
• Study First Submitted QC: 2018-01-25
• Study First Posted: 2018-01-26
• Primary Completion: 2018-02-01
• Study Completion: 2018-03-01
• Status Verified: 2018-04
• Last Update Submitted: 2018-04-30
• Last Update Posted: 2018-05-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Acne vulgaris patients
• Healthy volunteers (control)

Exclusion Criteria

• Patients with a history of drug intake that affects H. Pylori such as proton-pump inhibitors, clarithromycin, tetracyclines, amoxicillin or metronidazole within previous two weeks were excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
acne vlugaris group	Blood and stool samples collection	Included recruited patients with acne vulgaris Intervention: Blood and stool samples collection
Control group	Blood and stool samples collection	Included healthy participants Intervention: Blood and stool samples collection

Primary Outcome Measures

Name	Time	Method
H.pylori infection	one year	Prevalence of H.pylori infection among acne group and control group

Trial Locations

Locations (1)

Dermatology outpatient clinic, Sohag University Hospital; 🇪🇬 Sohag, Egypt