Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease

Completed

• Conditions: Hashimoto Disease

• Registration Number: NCT01102205
• Lead Sponsor: Vakif Gureba Training and Research Hospital

Brief Summary

Oxidative stress leads to or accompanies with numerous disease. Oxidative balance in subclinical hypothyroid or euthyroid state in Hashimoto disease are not known. Effect of levothyroxine therapy on oxidative balance are also not known in hashimoto disease.

Detailed Description

oxidative stress markers will be measured initially(TAS,TOS,OSI,PARAOXONASE,ARYLESTERASA,PON1 PHENOTYPİNG,LİPİDPEROXİD).After 3 months therapy with levothyroxine measurements will be repeated except PON1 phenotyping.

Study Timeline

• Study Start: 2010-04
• Primary Completion: 2010-04
• Study First Submitted: 2010-04-09
• Study First Submitted QC: 2010-04-12
• Study First Posted: 2010-04-13
• Study Completion: 2010-10
• Status Verified: 2013-06
• Last Update Submitted: 2013-06-11
• Last Update Posted: 2013-06-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

• age more than 18 years

Exclusion Criteria

• inability to give a written consent
• other conditions and drug usage affect oxidative stress

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Poxidative stress markers	After levotren therapy

Trial Locations

Locations (1)

Vakif Gureba Training and Research Hospital; 🇹🇷 Istanbul, Turkey