Isometric exercise for people with raised blood pressure

Not Applicable

Completed

• Conditions: Stage 1 hypertensive patients (defined as a clinic BP of 140-159/90-99 mmHg) who are not taking anti-hypertension medication; Circulatory System; Hypertensive diseases

• Registration Number: ISRCTN13472393
• Lead Sponsor: East Kent Hospitals University NHS Foundation Trust

Brief Summary

2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/34711266/ (added 01/11/2021) 2023 Other publications in https://pubmed.ncbi.nlm.nih.gov/36931669/ critical discussion of study feasibility and adaptations during the COVID-19 pandemic (added 24/03/2023) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/39187872/ Secondary outcome: embedded qualitative study on participant and stakeholder perceptions (added 29/08/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2020-09-18
• Study Completion: 2023-06-30
• Last Update Posted: 9 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

1. Aged 18 or over
2. Clinic systolic BP 140-159 mmHg
3. Able to provide informed consent

Exclusion Criteria

1. Currently taking anti-hypertensive medication
2. White coat hypertension, as evidenced by averaged home systolic BP <135 mmHg
3. Inability to undertake study intervention (isometric exercise)
4. Previous history of any of the following:
4.1. Diabetes mellitus (Type 1 or type 2)
4.2. Ischaemic heart disease (myocardial infarction and/or coronary angina and/or coronary revascularization procedure)
4.3. Moderate or severe stenotic or regurgitant heart valve disease
4.4. Atrial or ventricular arrhythmia
4.5. Stroke or transient ischaemic attack
4.6. Aortic aneurysm and/or peripheral arterial disease
4.7. Uncorrected congenital or inherited heart condition
5. Estimated glomerular filtration rate <45 ml/min (calculated using CKD-EPI or MDRD formulae, and taking most recent documented results)
6. Documented left ventricular ejection fraction <45% and/or left ventricular hypertrophy (by either echocardiography or standard ECG criteria e.g. Sokolow-Lyon)
7. Documented urine albumin:creatinine ratio >3.5 mg/mmol
8. Inability to provide informed consent
9. If female, pregnancy or currently breastfeeding
10. Enrolled in another Clinical Trial of an Interventional Medicinal Product or Medical Device or another interventional study
11. Medical condition that, in the opinion of the investigator, would make the participant unsuitable for the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified