NCT01593579撤回不适用
Autonomic Phenotype Before and After Akt Inhibition: Akt Therapy for Melanoma Sub-study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Drop in systolic blood pressure before and after Akt treatment
研究概览
简要总结
Some Akt inhibitors have produced functional cardiovascular effects such as marked hypotension that may limit their clinical benefit. There are no current data on whether this autonomic failure presents in humans at clinically used doses. We will test the hypothesis that Akt inhibition causes an acute decrease in sympathetic tone and lowers blood pressure.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with melanoma with a BRAF mutation and relapse following therapy with a BRAF inhibitor
- •Enrolled in a clinical trial through the Vanderbilt Ingram Cancer Center (VICC) including an arm with an oral Akt inhibitor
- •Able and willing to provide informed consent
排除标准
- •Factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule
- •Unable to give informed consent
结局指标
主要结局
Drop in systolic blood pressure before and after Akt treatment
时间窗: 8 hours
次要结局
未报告次要终点
研究者
Satish R. Raj
Assistant Professor
Vanderbilt University
研究点 (1)
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