To study the relationship between the total amount of fluid that has been accumulated in the body and the diaphragmatic function abnormalities among those patients with mechanical ventilator support
- Conditions
- Health Condition 1: J958- Other intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified
- Registration Number
- CTRI/2022/11/047421
- Lead Sponsor
- AIIMS NEW DELHI
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Patients (18-65 years) intubated for a duration of more than 48 hours and on controlled mechanical ventilator admitted in intensive care units, AIIMS New Delhi due to any medical/surgical reason.
1. Patients with pre-existing neuromuscular diseases (myasthenia gravis, Guillain-Barre syndrome, amyotrophic lateral sclerosis), cervical cord injury, diaphragmatic palsy
2. Pregnancy
3. Morbidly obese patient
4. Patients with poor diaphragmatic USG windows (presence of surgical dressings/ burns etc.)
5. Patients with a current pneumothorax or pneumomediastinum
6. Acute/worsening respiratory failure at or before day 3, any new onset respiratory failure defined as RR >35/min, P/F ratio <150 mm Hg, Type 1/2 failure.
7. Patients extubated before day3
8. Patients on long term steroid treatment
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation of cumulative fluid balance (CBF) with Diaphragm Thickness Fraction (DTF) at day 3 post intubationTimepoint: Day 3 post intubation
- Secondary Outcome Measures
Name Time Method CBF with diaphragmatic excursion during spontaneous breathing trialsTimepoint: during spontaneous breathing trial after day 3;CBF with diaphragmatic excursion post extubationTimepoint: post extubation day 1 and 2;CBF with diaphragmatic thickness fraction at day 5and 7Timepoint: at day 5 and 7 post intubation;CBF with difficult/prolonged weaningTimepoint: more than 7 days;CBF with duration of mechanical ventilatorTimepoint: 7 days