Phase 3, Multicenter, Randomized, Double-Blind, Parallel-group, Active-control Study to Evaluate the Safety and Efficacy of a Single Administration of SKY0402 for Prolonged Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy
Overview
- Phase
- Phase 3
- Intervention
- Bupivacaine HCl
- Conditions
- Hemorrhoids
- Sponsor
- Pacira Pharmaceuticals, Inc
- Enrollment
- 204
- Locations
- 20
- Primary Endpoint
- Area Under the Curve (AUC) of the Numeric Rating Scale at Rest (NRS-R) Pain Intensity Scores
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Effective postoperative pain control to promote improved healing, faster patient mobilization, shortened hospital stays, and reduced healthcare costs.
Detailed Description
Effective postoperative pain control is a critical element in patient recovery, as the majority of patients may experience significant pain, particularly in the first few days following surgery. Appropriate postoperative pain management contributes to improved healing, faster patient mobilization, shortened hospital stays, and reduced healthcare costs.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Male or female equal or greater than 18 years of age at Screening
- •Female subjects: postmenopausal, surgically sterile, or willing to use acceptable means of contraception for at least 30 days after surgery, nonheterosexual lifestyle, or strictly monogamous relationship with a partner who has had a vasectomy.
- •Scheduled to undergo 2-or3-column excisional hemorrhoidectomy
- •American Society of Anesthesiology (ASA) Physical Class 1-4
- •Able and willing to complete with all study visits and procedures
- •Able to speak, read, and understand the language of all study forms and instruments used for collecting subject-reported outcomes to provide accurate study assessments
- •Willing and capable of provide written informed consent.
Exclusion Criteria
- •Pregnant, nursing or planning to become pregnant during the study period
- •Use of any long-acting opioid medication within 3 days of surgery or any opioid medication with 24 hours of surgery.
- •Concurrent painful physical condition or concurrent surgery that may require analgesic treatment in the postoperative period for pain not strictly related to the procedure or that may interfere with study assessments.
- •Single-column hemorrhoidectomy
- •Body weight less than 50 kg (110 pounds)
- •History of hypersensitivity or idiosyncratic reaction to amide-type local anesthetics, opioid medication, or any ingredient of the medications administered in this study (e.g., sulfites in Marcaine with epinephrine)
- •contraindication to epinephrine
- •contraindication to any of the pain-control agents planned for postoperative use
- •Administration of an investigational drug within 30 days or 5 elimination half-lives of such investigational drug prior to study drug administration
- •History of, known addiction, or abuse of illicit drugs, prescription medicines or alcohol within the past 2 years.
Arms & Interventions
Bupivacaine HCl
100 mg Bupivacaine HCl (e.g., Marcaine with epinephrine 1:200,000) is the reference-listed drug for bupivacaine and contains the same active, local anesthetic as SKY0402. A single dose of study drug was administered intraoperatively (at the end of surgery) via local infiltration.
Intervention: Bupivacaine HCl
SKY0402
300 mg SKY0402 in a 40-mL injection volume. A single dose of study drug was administered intraoperatively (at the end of surgery) via local infiltration.
Intervention: SKY0402
Outcomes
Primary Outcomes
Area Under the Curve (AUC) of the Numeric Rating Scale at Rest (NRS-R) Pain Intensity Scores
Time Frame: through 96 hours
To assess pain intensity at rest (NRS-R), the subject was to assume a resting position that did not exacerbate his or her postoperative pain. The subject was to rest in this position for at least 5 minutes before responding to the following question, "On a scale of 0 to 10, where 0=no pain and 10=worst possible pain, how much pain are you having right now?"
Secondary Outcomes
- Number of Participants With Adverse Events (AEs) Through Day 3 and Serious Adverse Events (SAEs) Through Day 30(through day 30)