Identification of New Highly Antibiotic-resistant Bacteria Carriage Risk Factors to Optimize the Detection and Medical Care for Carriers Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,396
- 试验地点
- 1
- 主要终点
- Risk factors
研究概览
简要总结
The aim of this study is to identify in hospitalized patients, the risk factors associated with the digestive colonisation by emergent extensively drug-resistant bacteria (eXDR), to optimize their detection and the medical care for carriers these patients
详细描述
CODBAHRE is a french, regional study, involving 9 centers. Recruitment will take place in all the departments of the centers involved under the supervision of the Infection Control Team.
All patients hospitalized more than 24 hours, on a given day are eligible for the protocol, except the patients unable to answer the questionnaire.
After collecting the non-opposition of the patient, patients will be screened by rectal swab and a questionnaire will be completed.
Each sample will be analyzed to detect eXDR carrying patients.
The carrying patients will be followed during 6 months to estimate the proportion of the population which developped a bacterial infection. This information will be collected by a retrospective telephone survey of carrying patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalization of more than 24 hours
- •Give his no objection
排除标准
- •Hospitalization in psychiatry
- •Unwilling to participate
结局指标
主要结局
Risk factors
时间窗: at inclusion
Identification of risk factors for digestive colonisation by highly resistant bacteria Lifestyle questionnaire: environment, diet, medical history and result of the rectal swab
次要结局
- Proportion of patients carrying "eXDR" who will develop an infection with the same germ referred to the number of eXDR carriers(6 months)
- Prevalence of co-carrying patients of eXDR and ESBL will be determined by the number of patients who carrying eXDR and ESBL referred to the number of patients sampled(1 day)
- Cross-transmission rate of eXDR(1 day)
- Description of the association between strains (RAPD, infrared Biotyper, genome sequencing).(16 months)
- Comparison of the frequency of positive presence of eXDR bacteria obtained between culture technic and molecular biology technic(16 months)
- Prevalence of multidrug-resistant bacteria will be determined by the number of patients who have been detected at least one multidrug-resistant bacteria referred to the number of patients sampled(1 day)
- Description of resistance and virulence characteristics between strains (RAPD, infrared Biotyper, genome sequencing).(16 months)
- Prevalence will be determined by the number of patients who carrying at least one Multidrug-resistant bacteria referred to the number of patients sampled(1 day)