Involuntary Memories Investigation in Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 65
- 试验地点
- 2
- 主要终点
- Autobiographical subjective score taking into account memories vividness and specifity
研究概览
简要总结
Patients with schizophrenia suffer from autobiographical memory disorders. Patients have difficulty to remember vividly personal past events when they are specifically asked for. Indeed, this task requires a good executive functioning to retrieve precise information stored in long term memory. Interestingly, executive functioning has been showed impaired in schizophrenia and studies showed that their autobiographical memory impairments were directed related to their executive dysfunction.
Yet, in daily life people remember more often autobiographical memories spontaneously, without trying voluntarily to recall them.
In that case, the involuntary recall of personal past events is much less sustained by executive functioning.
In this protocol the investigators would like to investigate and compare subjective characteristics of involuntary and voluntary autobiographical memories in order to highlight the role of executive dysfunction in patients' autobiographical memory impairments.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- for patients only
- •male or female
- •age limits : 18-55 years old
- •under the protection of health insurance
- •who have signed up the consent form
- •schizophrenia or schizo-affective disorder according to the DSM-5 criteria (APA, 2013).
- •clinically stable for at least 2 months
- •patients under guardianship or curatorship need agreement of their legal representative
- •informed of the results of prior medical examination for controls only
- •male or female
- •age limits : 18-55 years old
- •under the protection of health insurance
- •who have sign up the consent form
- •recruited from the general population and matched on gender, age years of schooling
- •no psychiatric history (DSM-5)
排除标准
- •for both patients and controls
- •current severe or unstable somatic illness
- •neurological history (brain injury > 15 minutes loss of consciousness , epilepsia, brain surgery...)
- •current substance use disorder (DSM-5)
- •current major depressive disorder (CDSS,BDI, HDRS)
- •mental retardation (IQ < 70, WAIS-4, f-NART)
- •history of general anesthesia 3 months prior to the experiment
- •pregnancy declared by the subject
- •breast feeding
- •current legal control
- •in emergency situation
- •included during exclusion period in another experiment
- •for controls only
- •taking of antipsychotic drugs for the 3 weeks prior to inclusion
- •under guardianship or curatorship
结局指标
主要结局
Autobiographical subjective score taking into account memories vividness and specifity
时间窗: 8 months
次要结局
未报告次要终点