Aspirin and colorectal cancer prevention. Exploring the platelet hypothesis of its mechanism of action

Insituto Aragonés de Ciencias de la Salud0 个研究点开始时间: 2014年3月19日最近更新: 2014年3月24日

适应症

试验速览

暂无简介。

•1.Patients should be ? 18 years and no older than 69
•2.Patients should have an indication for screening colonoscopy (patients > 50 years or personal or familiar history of CCR or adenomas )
•a.First degree relative of patient with CRC.
•b.Personal history of adenomas.
•c.People older than 50 and FOBT positive
•3.Routine hematological and biochemical parameters within the normal range
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 40
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 40

•1.Allergy to aspirin or other NSAIDs.
•2.Previous use of aspirin, NSAIDS, antiplatelet agents, corticosteroids or misoprostol in the previous 15 days and/or anticipated need for these drugs during the study period.
•3.Peptic ulcer history or any other gastrointestinal disease that could be considered a contraindication for aspirin use without the concomitant use of a proton-pump inhibitor
•4.Subjects with a bleeding disorder
•5.Malignancies, excluding CRC, diagnosed in the previous 5 years
•6.Serious comorbid condition, including pulmonary, cardiac, liver or kidney diseases, cigarette smoking, history of drug or alcohol abuse
•7.Pregnant women or breast feeding

发起方

Insituto Aragonés de Ciencias de la Salud