Autoimmune Phenomena After Acute Stroke - the Role of Stroke-induced Immunodepression
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 28
- Locations
- 1
- Primary Endpoint
- autoantigen-specific T-cells in patients with acute media infarct
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The damage of the brain parenchyma, as well as the stroke-induced dysfunction of the blood-brain-barrier can make previously hidden CNS antigens "visible", and can thus lead to the development of autoimmune mechanisms.
It seems plausible that stroke-associated immunodepression influences the development and the phenotype of these autoreactive immune responses.
This study will investigate whether cerebral ischemia leads to changes in the immune response, in particular to the development and/or proliferation of autoreactive effector T-cells and/or regulatory T-cells. Furthermore, the association between the severity and the phenotype of this autoimmune response and the clinical course, i.e. prognosis and mortality, will be investigated.
Investigators
Andreas Meisel
Professor Dr. med.
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •acute media infarct or intracerebral bleeding within the last 36 h (patients)
- •NIHSS \> 7 (patients)
- •age \> 17 years (patients), age \> 54 years (controls)
- •informed consent of patient or legal representative/ of control
- •cardiovascular risk such as diabetes mellitus (control)
Exclusion Criteria
- •infections (patients, controls)
- •antibiotic or immunosuppressive treatment within the last 4 weeks (patients)
- •other CNS disorders
Outcomes
Primary Outcomes
autoantigen-specific T-cells in patients with acute media infarct
Time Frame: within 36 h
quantitative determination of autoantigen-specific T-cells in patients with acute media infarct
leukocytes in patients with acute media infarct
Time Frame: within 36 hours
quantitative and qualitative analysis of leukocytes in patients with acute media infarct
Secondary Outcomes
- frequency and phenotype of CNS-autoreactive immune cells under the influence of immunodepression(within 36 h, after day 3, 7, 90 and 180)
- clinical course, i.e. mortality and prognosis (measured by mod. Rankin Scale)(after day 90 and 180)
- clinical course, i.e. mortality and prognosis (measured by Bartel Index)(after day 90 and 180)