Autoimmune Phenomena After Acute Stroke - the Role of Stroke-induced Immunodepression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- autoantigen-specific T-cells in patients with acute media infarct
研究概览
简要总结
The damage of the brain parenchyma, as well as the stroke-induced dysfunction of the blood-brain-barrier can make previously hidden CNS antigens "visible", and can thus lead to the development of autoimmune mechanisms.
It seems plausible that stroke-associated immunodepression influences the development and the phenotype of these autoreactive immune responses.
This study will investigate whether cerebral ischemia leads to changes in the immune response, in particular to the development and/or proliferation of autoreactive effector T-cells and/or regulatory T-cells. Furthermore, the association between the severity and the phenotype of this autoimmune response and the clinical course, i.e. prognosis and mortality, will be investigated.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •acute media infarct or intracerebral bleeding within the last 36 h (patients)
- •NIHSS > 7 (patients)
- •age > 17 years (patients), age > 54 years (controls)
- •informed consent of patient or legal representative/ of control
- •cardiovascular risk such as diabetes mellitus (control)
排除标准
- •infections (patients, controls)
- •antibiotic or immunosuppressive treatment within the last 4 weeks (patients)
- •other CNS disorders
结局指标
主要结局
autoantigen-specific T-cells in patients with acute media infarct
时间窗: within 36 h
quantitative determination of autoantigen-specific T-cells in patients with acute media infarct
leukocytes in patients with acute media infarct
时间窗: within 36 hours
quantitative and qualitative analysis of leukocytes in patients with acute media infarct
次要结局
- frequency and phenotype of CNS-autoreactive immune cells under the influence of immunodepression(within 36 h, after day 3, 7, 90 and 180)
- clinical course, i.e. mortality and prognosis (measured by mod. Rankin Scale)(after day 90 and 180)
- clinical course, i.e. mortality and prognosis (measured by Bartel Index)(after day 90 and 180)
研究者
Andreas Meisel
Professor Dr. med.
Charite University, Berlin, Germany