Comparing two different doses of praziquantel in Lao school children to treat infections of Schistosoma mekongi and Opisthorchis viverrini

Completed

• Conditions: Schistosoma mekongi and Opisthorchis viverrini infections; Infections and Infestations; Schistosoma mekongi infection

• Registration Number: ISRCTN57714676
• Lead Sponsor: Swiss Tropical and Public Health Institute (Switzerland)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-05-05
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 308

Inclusion Criteria

1. School children (males and females) between 6-16 years

Exclusion Criteria

1. Pregnancy
2. Severe illness
3. Non-consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Schistosoma mekongi and Opisthorchis viverrini infection clearance (no eggs in 3 stool samples examined with Kato-Katz technique) at 28 and 90 days after treatment.

Secondary Outcome Measures

Name	Time	Method
1. Reduction of intensity of infection (reduction of mean number of S. mekongi and O.viverrini eggs per gram of stool sample assessed by Kato-Katz technique) at 28 and 90 days after treatment<br>2. Diagnostic sensitivity of increasing number of Kato-Katz thick smears before and 28 days after treatment. 'Gold' standard: 9 Kato-Katz thick smears (applied on a sub-sample of the population)