Blackcurrant juice study: a study to investigate the biokinetics and effects of a blackcurrant juice on endothelial functio
Completed
- Conditions
- Absorption of phytochemicals and effects on endothelial functionNutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN26166772
- Lead Sponsor
- GlaxoSmithKline Nutritional Healthcare (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
1. Men and women between the ages of 30-70 years
2. Normal weight
3. Drink no more than 15 units of alcohol (i.e. not more than 7 pints) per week
4. Not regularly undertaking vigorous exercise or fitness training (i.e. not more than 3, 20 minute aerobic sessions per week)
Exclusion Criteria
1. Diabetes
2. Heart disease
3. Gall bladder problems
4. Phenylketonuria (PKU)
5. Known food allergies or intolerances or abnormalities of fat metabolism
6. Trying to lose weight or following other diets
7. Taking dietary supplements
8. Hormone abnormalities or liver disease
9. Regularly use certain types of medication
10. Pregnant, lactating or, if female and of reproductive age, not using a reliable form of contraception (including abstinence)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endothelial function/vascular reactivity assessed by laser doppler iontophoresis at 0 and 120 minutes.
- Secondary Outcome Measures
Name Time Method Phytochemical composition (phenolic acids and flavonoids) of plasma and urine was measured at 0.5 hour intervals for the first 4 hours, then 1 hour intervals up to 8 hours. A 24 hour urine sample was also analysed.