Intranasal TXA for Anterior Epistaxis in the Emergency Department
试验速览
- 阶段
- 2 期
- 状态
- 暂停
- 发起方
- 入组人数
- 86
- 试验地点
- 2
- 主要终点
- Bleeding cessation
研究概览
简要总结
The objective of this study is to evaluate the efficacy of and patient satisfaction with the use of intranasal tranexamic acid (TXA) for anterior nosebleeds in the emergency department (ED).
详细描述
Pledget soaked in either saline or TXA will be applied to the bleeding nare of the patient presenting with anterior epistaxis. After fifteen minutes, the pledget will be removed and patient reassessed.
Informed consent will be obtained prior to patient enrollment.
Enrolled patients will be placed in one of two groups: either the group receiving a cotton pledget soaked in (0.9%) saline or (100mg/1mL) TXA. Patients will initially be asked to gently blow their nose to remove any clots. Group 1 will receive the saline soaked pledget. After fifteen minutes the pledget will be removed. If patient continues to bleed within a reevaluation period of fifteen minutes, this will be deemed a 'failure' and the examiner will pack the nose with the method of his or her choice. Group 2 will receive the TXA soaked pledget and the procedure will continue like Group 1.
Patient satisfaction will be assessed in both groups during ED stay and one week after ED stay.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
TXA
Research participants in the experimental group will receive one dose of 100mg/mL TXA soaked in a cotton pledget in the bleeding nare for a total of 15 minutes.
干预措施: Tranexamic Acid (Drug)
Saline
Research participants in the placebo group will receive one dose of normal saline (0.9%) soaked in a cotton pledget in the bleeding nare for a total of 15 minutes.
干预措施: Placebo (Other)
结局指标
主要结局
Bleeding cessation
时间窗: 15 minutes
After 15 minutes of patient receiving either pledget filled TXA or placebo, bleeding will be assessed
次要结局
- Patient satisfaction: 10 point scale(Before ED discharge (up to 24 hours) and 1 week after ED discharge)
- Bleeding cessation(1 week)