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临床试验/NCT06546956
NCT06546956
已完成
1 期

Developing and Testing a Multicomponent Breathwork Intervention for Adults With Chronic Pain

University of Florida1 个研究点 分布在 1 个国家目标入组 19 人2024年10月24日

概览

阶段
1 期
干预措施
Integrative Breathwork Intervention
疾病 / 适应症
Chronic Low-back Pain
发起方
University of Florida
入组人数
19
试验地点
1
主要终点
Treatment Acceptability
状态
已完成
最后更新
18天前

概览

简要总结

The proposed research is to develop and refine a multicomponent breathwork intervention, Guided Respiration Mindfulness Therapy, and to iteratively evaluate its feasibility, acceptability, and plausibility for clinically significant effects in people with chronic low back pain. This integrative breathwork intervention involves a 60-minute breathing session where the focus is to maintain a conscious connected breathing pattern (no pause between inhale and exhale), apply mindful acceptance to somatic sensations, and relax any physical tension. Each breathwork session will be delivered 1-on-1 in person by a trained facilitator. The treatment consists of 8 breathwork sessions, once per week for 8 weeks.

详细描述

Multiple single-arm iterations of an 8-week breathwork intervention will be conducted to refine and optimize the intervention and protocol. Upon completion of each iteration, quantitative and qualitative data will be gathered to identify possible modifications before proceeding with the next iteration. This work will provide initial evidence on the feasibility, acceptability, and plausibility of clinically significant effects of this type of multicomponent breathwork intervention for adults with chronic low back pain.

注册库
clinicaltrials.gov
开始日期
2024年10月24日
结束日期
2026年1月9日
最后更新
18天前
研究类型
Interventional
研究设计
Single Group
性别
All

研究者

责任方
Sponsor

入排标准

入选标准

  • Men and women 18-70 years of age.
  • Chronic primary low back pain that has persisted for at least 3 months and on most days for the past 6 months.
  • Average pain intensity of ≥ 4/10 for the past month.
  • Fluent in English.
  • Access to internet with a valid email address.
  • Able to lay down and stay relatively still for one hour.

排除标准

  • Leg pain, or any other chronic pain, that is greater than low back pain.
  • Back pain possibly due to specific conditions (e.g., cancer, infection).
  • Ongoing legal action or disability claim related to low back pain.
  • Neurological symptoms associated with low back pain, including loss of control or incontinence of bowel or bladder.
  • Systemic rheumatic disease/condition (e.g. rheumatoid arthritis, systemic lupus erythematosus, fibromyalgia).
  • Respiratory disorder (e.g., chronic obstructive pulmonary disease) or moderate to severe asthma within the past 12 months.
  • Activity limiting heart disease including cardiovascular or peripheral arterial disease.
  • Uncontrolled hypertension (i.e. SBP/DBP of \> 160/95) or orthostatic hypotension (e.g., issues with fainting).
  • Neurological disease (e.g. Parkinson's, multiple sclerosis, epilepsy, history of seizures) or evidence of previous brain injury, including stroke and traumatic brain injury.
  • Serious acute physical injuries or any surgery within the past 6 months.

研究组 & 干预措施

Integrative Breathwork Intervention

The integrative, multicomponent breathwork intervention that will be tested in this study is called Guided Respiration Mindfulness Therapy. Participants will receive a 60 minute breathwork session once a week for 8 weeks.

干预措施: Integrative Breathwork Intervention

结局指标

主要结局

Treatment Acceptability

时间窗: Post-treatment (after the 8-week intervention)

Treatment acceptability and participant satisfaction of the breathwork intervention will be measured using the Client Satisfaction Questionnaire and several face valid items. (0-10; higher values = greater treatment acceptability and satisfaction).

Participant Retention

时间窗: Post-treatment (Week 8)

Percentage of randomized participants who complete post-treatment assessment.

Intervention Adherence

时间窗: Post-treatment (Week 8)

Percentage of intervention sessions attended by participants.

Change in Pain Intensity

时间窗: Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.

The Pain, Enjoyment, and General Activities (PEG-3) scale will be used to assess pain intensity over the past week on average. (0-10; higher values = greater pain intensity).

Change in Pain Interference

时间窗: Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.

The Pain, Enjoyment, and General Activities (PEG-3) will be used assess pain interference over the past week. (0-10; higher values = greater pain interference).

次要结局

  • Change in Fear Avoidance Beliefs(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Change in Fatigue(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Change in Stress(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Change in Interoception(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Change in Mindful Reappraisal of Pain Sensations(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Treatment Credibility(After Intervention session 3)
  • Change in Anxiety(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Acute Treatment Effects(Before and after each intervention sessions (Weeks 1-8))
  • Change in Physical Function(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Change in Sleep Disturbance(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Change in Multisensory Sensitivity(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Change in Pain Catastrophizing(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Change in Depression(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Change in Pain Self-Efficacy(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)
  • Change in Sleep Related Impairment(Change from Baseline (Week 0) to Post-treatment (Week 8), 1-month follow-up.)

研究点 (1)

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