Effects of COVID-19 Induced Deconditioning After Long-term High Intensity Resistance Exercise in Older Men With Osteosarcopenia A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Osteoporosis
- Sponsor
- University of Erlangen-Nürnberg Medical School
- Enrollment
- 21
- Locations
- 1
- Primary Endpoint
- SMI
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. Dynamic-resistance exercise (DRT) might be the most powerful agent to fight osteosarcopenia. Indeed, in the present FrOST study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (HIT)-DRT on bone mineral density (BMD), sarcopenia and other health related parameters in osteosarcopenic men. However, after a short training break, COVID-19 induced lock down prevented a re-start of the HIT resistance exercise training in the FrOST cohort.
The aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.
Investigators
Eligibility Criteria
Inclusion Criteria
- •participants of the FrOST study (NCT03453463)
Exclusion Criteria
- •medication and diseases with potential impact on study outcomes during the last 26 weeks.
Outcomes
Primary Outcomes
SMI
Time Frame: Change from Baseline to 26 weeks
Skeletal muscle mass index (appendicular skeletal muscle mass / body height; kg/m2) as determined by Dual Energy x-Ray Absorptiometry
Secondary Outcomes
- Maximum hip-/leg extensor strength(Change from Baseline to 26 weeks)
- BMD-hip(Change from Baseline to 26 weeks)
- Metabolic Syndrome Z-Score(Change from Baseline to 26 weeks)
- BMD-LS(Change from Baseline to 26 weeks)
- Fat infiltration thigh muscles(Change from Baseline to 26 weeks)
- Fat infiltration para-vertebral muscles(Change from Baseline to 26 weeks)
- Self rated physical performance(Change from Baseline to 26 weeks)
- Sarcopenia-Z-Score(Change from Baseline to 26 weeks)