Effects of COVID-19 Induced Deconditioning After Long-term High Intensity Resistance Exercise in Older Men With Osteosarcopenia A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- SMI
研究概览
简要总结
Osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. Dynamic-resistance exercise (DRT) might be the most powerful agent to fight osteosarcopenia. Indeed, in the present FrOST study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (HIT)-DRT on bone mineral density (BMD), sarcopenia and other health related parameters in osteosarcopenic men. However, after a short training break, COVID-19 induced lock down prevented a re-start of the HIT resistance exercise training in the FrOST cohort.
The aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 74 Years 至 95 Years（Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •participants of the FrOST study (NCT03453463)
排除标准
- •medication and diseases with potential impact on study outcomes during the last 26 weeks.
结局指标
主要结局
SMI
时间窗: Change from Baseline to 26 weeks
Skeletal muscle mass index (appendicular skeletal muscle mass / body height; kg/m2) as determined by Dual Energy x-Ray Absorptiometry
次要结局
- Maximum hip-/leg extensor strength(Change from Baseline to 26 weeks)
- BMD-hip(Change from Baseline to 26 weeks)
- Metabolic Syndrome Z-Score(Change from Baseline to 26 weeks)
- BMD-LS(Change from Baseline to 26 weeks)
- Fat infiltration thigh muscles(Change from Baseline to 26 weeks)
- Fat infiltration para-vertebral muscles(Change from Baseline to 26 weeks)
- Self rated physical performance(Change from Baseline to 26 weeks)
- Sarcopenia-Z-Score(Change from Baseline to 26 weeks)