Depression and Posttraumatic Stress Disorder in Stroke Patients: an Observational Study of Neuro-psychiatric, Cognitive, and MR-Changes Over Time After Stroke
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 84
- Locations
- 1
- Primary Endpoint
- occurence of depression (GDS, SKID)
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Neuro-psychological, cognitive and biochemical assessment matched with MR-Imaging in acute and chronic poststroke conditions.
Detailed Description
The study design relates to affective symptomatology, particularly poststroke depression and posttraumatic stress symptoms as well as to cognitive decline due to stress-related hypercortisolemia in the early phase after stroke. Extended MRI studies including a functional connectivity (fc-MRI) paradigm have been incorporated to study on subacute midbrain neurodegeneration as a possible morphological correlate of functional and clinical findings.
Investigators
Matthias Endres
Prof. MD
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •Stroke in MCA/AchA territory of striato-capsular (at least 125mm³) or non-striatal (10-100cm³) involvement
- •MR-imaging can be conducted 24-48 hours of onset
- •preserved communication skills
Exclusion Criteria
- •Patients with psychiatric conditions or medication in the last 4 weeks
- •severe medical conditions
- •limited prognosis
Outcomes
Primary Outcomes
occurence of depression (GDS, SKID)
Time Frame: 90 days
Geriatric Depression Scale, Structured Clinical interview for DSM-IV
Secondary Outcomes
- change in serumcholine(90days)
- change in saliva cortisol(90days)