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Clinical Trials/NCT03833817
NCT03833817
Completed
N/A

A Communication-based Intervention for Advanced Cancer Patient-caregiver Dyads to Increase Engagement in Advance Care Planning and Reduce Caregiver Burden

Weill Medical College of Cornell University1 site in 1 country28 target enrollmentSeptember 20, 2020
ConditionsAdvanced Cancer

Overview

Phase
N/A
Intervention
Not specified
Conditions
Advanced Cancer
Sponsor
Weill Medical College of Cornell University
Enrollment
28
Locations
1
Primary Endpoint
Change in Prognostic Understanding
Status
Completed
Last Updated
3 years ago

Overview

Brief Summary

The purpose of this study is to: (1) develop a communication-based intervention to improve advanced cancer patients' and caregivers' prognostic understanding using communication strategies (e.g., acknowledgment, validation of fears) and distress management techniques (e.g., deep breathing, muscle relaxation); (2) evaluate the feasibility and acceptability of the intervention among advanced cancer patients and their caregivers; and (3) test the preliminary efficacy of the intervention on patients' and caregivers' prognostic understanding (primary outcome); completion of DNR order, living will, and health care proxy; psychological distress; communication quality; caregiver burden; and healthcare utilization (secondary outcomes).

Registry
clinicaltrials.gov
Start Date
September 20, 2020
End Date
January 18, 2022
Last Updated
3 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Diagnosis of poor prognosis advanced cancer defined as locally advanced or metastatic cancer (e.g., pancreaticobiliary, esophagogastric, hepatocellular carcinoma, lung, or gynecological cancer) and/or disease progression following at least first line chemotherapy.
  • Ability to provide informed consent
  • Identification of an informal caregiver
  • Oncologist reported discussion of prognosis with the patient and/or caregiver.

Exclusion Criteria

  • Not fluent in English
  • Severely cognitively impaired (as measured by Short Portable Mental Status Questionnaire scores of \< 6)
  • Too ill or weak to complete the interviews (as judged by the interviewer)
  • Currently receiving palliative care/hospice at the time of enrollment
  • Children and young adults under age 18
  • Deemed inappropriate for the study by their treating oncologist.
  • In addition, patient-caregiver dyads in which both members have an accurate understanding of prognosis (terminal status and life-expectancy) will be excluded due to the lack of need for an intervention.
  • Caregiver inclusion criteria:
  • The person (family member or friend) whom the patient indicates provides their informal (unpaid) care
  • English speaking

Outcomes

Primary Outcomes

Change in Prognostic Understanding

Time Frame: Baseline, post-intervention (within 30 days)

Change in prognostic understanding is assessed at baseline and post-intervention with two items on prognostic understanding: (1) Terminal illness acknowledgement with the item "How would you describe your current health status?" Answer choices include: 1) Relatively healthy, 2) relatively healthy but terminally ill, 3) seriously ill but not terminally ill, and 4) seriously ill and terminally ill, and (5) I don't know\]. Responses 2 and 4 are coded as accurate and responses 1, 3, and 5 are coded as inaccurate. (2) Life-expectancy \[Months, Years, and "I don't know"\]. Months are coded as accurate and years and I don't know are coded as inaccurate. Each variable is coded as 0=inaccurate or 1=accurate, for a total summary score range of 0 to 2. Differences between baseline and post-intervention assessments are calculated (possible range, -2 to +2) to determine changes in prognostic understanding.

Secondary Outcomes

  • Change in Patients' Engagement in Advance Care Planning, as Measured by the Quality of Life Subscale of the Advance Care Planning Engagement Survey: Action Measures, From Baseline to Post-intervention(Baseline, post-intervention (within 30 days))
  • Change in Caregivers' Engagement in Advance Care Planning, as Measured by the Van Scoy and Sudore Measure Which Adapts the Decision Maker Subscale of the Advance Care Planning Engagement Survey, From Baseline to 3-month Follow-up(Baseline, follow-up (3 months))
  • Change in Communication Quality, as Measured by the Family Communication Subscale of the Cancer Communication Assessment Tool for Patients and Families (CCAT-PF)(Baseline, post-intervention (within 30 days))
  • Change in Caregiver Burden (Caregivers Only), as Measured by the Zarit Burden Interview(Baseline, post-intervention (within 30 days))
  • Change in Patients' Engagement in Advance Care Planning, as Measured by the Decision Maker Subscale of the Advance Care Planning Engagement Survey: Action Measures, From Baseline to Post-intervention(Baseline, post-intervention (within 30 days))
  • Change in Patients' Engagement in Advance Care Planning, as Measured by the Quality of Life Subscale of the Advance Care Planning Engagement Survey: Action Measures, From Baseline to 3-month Follow-up(Baseline, follow-up (3 months))
  • Change in Caregivers' Engagement in Advance Care Planning, as Measured by the Van Scoy and Sudore Measure Which Adapts the Decision Maker Subscale of the Advance Care Planning Engagement Survey, From Baseline to Post-Intervention(Baseline, post-intervention (within 30 days))
  • Change in the Number of Advance Directives Completed(Baseline, post-intervention (within 30 days))
  • Change in Patients' Engagement in Advance Care Planning, as Measured by the Decision Maker Subscale of the Advance Care Planning Engagement Survey: Action Measures, From Baseline to 3-month Follow-up(Baseline, follow-up (3 months))
  • Change in Psychological Distress, as Measured by the Hospital Anxiety and Depression Scale (HADS)(Baseline, post-intervention (within 30 days))

Study Sites (1)

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