Perioperative Use of Serum Creatinine and Postoperative Acute Kidney Injury

Completed

• Conditions: Acute Kidney Injury; Surgery; Malignancy; Cronich Kidney Disease
• Interventions: Diagnostic Test: Serum creatinine

• Registration Number: NCT04341974
• Lead Sponsor: Careggi Hospital

Brief Summary

The perioperative approach adopted in a cohort of adult oncological patients undergoing major abdominal surgery will be described. In particular, the physician's attitude toward use of sCr for identification of patients at risk for PO-AKI will be described, as well as the patients who should be reassessed in the long term for progression toward CKD. The incidence and risk factors associated with PO-AKI and renal function deterioration within a year postoperatively will be also evaluated.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-01
• Primary Completion: 2020-01-01
• Study Completion: 2020-03-31
• Status Verified: 2020-04
• Study First Submitted: 2020-04-08
• Study First Submitted QC: 2020-04-08
• Study First Posted: 2020-04-10
• Last Update Submitted: 2020-04-10
• Last Update Posted: 2020-04-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 423

Inclusion Criteria

• Adult patients
• Scheduled for elective surgery
• Surgery for oncological disease

Exclusion Criteria

• Patients undergoing postoperative chemotherapy
• Patients who died within 12 month after surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
surgical patients	Serum creatinine	Adult patients undergoing major elective general abdominal surgery for ontological disease

Primary Outcome Measures

Name	Time	Method
Adoption of serum creatinine as marker of acute kidney injury postoperively	3rd postoperative day	Number of actual patients screened postoperatively

Secondary Outcome Measures

Name	Time	Method
Adoption of serum creatinine as marker of long term kidney dysfunction	12 month after surgery	Number of actual patients screened at the long term
Incidence of long term kidney dysfunction	12 month after surgery	Number of patients with a long term reduction in GFR greater than 10 ml/min with respect to the baseline
Incidence of acute kidney injury	3rd postoperative day	Number of patients with a postoperative diagnostic increase of serum creatinine, in accordance with KDIGO guidelines

Trial Locations

Locations (1)

Azienda Ospedaliero Universitaria Careggi; 🇮🇹 Florence, Italy