NCT03700164CompletedNot Applicable
The Effect of Cold Exposure on the Glycaemic and Insulinaemic Responses to an Oral Glucose Load
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Maastricht University
- Enrollment
- 16
- Locations
- 2
- Primary Endpoint
- Glucose and insulin concentrations in response to an oral glucose load
Study Overview
Brief Summary
The purpose of the study is to evaluate the effect of cold exposure on an individual's glucose tolerance. Previous research has already shown that 10 days acclimation to a mild cold environment (14-15°C) can enhance insulin sensitivity. However, the duration in the cold environment was 6 hours per day which may not be practical for everyone. Therefore, the present study will investigate the effect of a shorter, and more intense cold exposure on an individual's glucose tolerance. It is hypothesised that cold exposure before consuming a glucose drink will enhance glucose clearance.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Glucose and insulin concentrations in response to an oral glucose load
Time Frame: 3 hours post glucose drink, measured 90 minutes after the cold exposure
Secondary Outcomes
- Skin temperature measured using iButtons(30 minutes before and during the 1 hour of cold exposure)
- Systolic and diastolic blood pressure measured using an automatic blood pressure device(30 minutes before and during the 1 hour of cold exposure)
- Thermal sensation(30 minutes before and during the 1 hour of cold exposure)
- Comfort(30 minutes before and during the 1 hour of cold exposure)
- Energy expenditure measured using indirect calorimetry(30 minutes before and during the 1 hour of cold exposure)
- Core temperature measured using a telemetric pill(30 minutes before and during the 1 hour of cold exposure)
- Shivering activity assessed using surface electromyography(30 minutes before and during the 1 hour of cold exposure)
- Heart rate measured using chest heart rate monitor sensor(30 minutes before and during the 1 hour of cold exposure)
- Skin blood flow measured using laser doppler flowmetry(30 minutes before and during the 1 hour of cold exposure)
Investigators
Study Sites (2)
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