Quantification of Respiratory-induced Prostate Motion
- Conditions
- Prostate Cancer
- Registration Number
- NCT00980993
- Lead Sponsor
- Oregon Health and Science University
- Brief Summary
Patient anatomy and position during the course of radiation therapy can vary from those used for treatment planning; a function of patient movement, uncertainty in positioning system, and organ motion. Traditionally, treatment margins are designed to compensate for interfraction prostate setup variability. This approach has the potential to lower the overall effectiveness of treatment because the prostate gland is a continuously moving target whose motion cannot be accurately accounted for solely on the basis of interfraction movement. More recently, the dosimetric relevance of intra-fraction prostate motion has been recognized, and may be compensated for by continuous real-time adaptive radiation therapy afforded by the Calypso 4D Localization System™. In the current study, the investigators propose to characterize intrafraction prostate motion. The investigators hypothesize that intrafraction prostate motion is correlated with respiratory motion.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- Male
- Target Recruitment
- Not specified
- Histologically confirmed stage I-III adenocarcinoma of the prostate gland
- Age > 18 years. Males of all races and ethnic groups
- Scheduled to receive radiation for definitive therapy
- Three (3) electromagnetic transponders implanted into prostate gland
- Does not satisfy inclusion criteria
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Motion amplitude Continuously during radiation administration (generally 8 to 15 minutes in duration) Measured at frequency of 10Hz
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Oregon Health and Science University
🇺🇸Portland, Oregon, United States