Liver Enzyme Abnormalities and Its Risk Factors in Taking Traditional Herbal Medicine in Korea
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 6,894
- 试验地点
- 1
- 主要终点
- Aspartate aminotransferase (AST)
研究概览
简要总结
Herb-induced liver injury is an important issue in musculoskeletal diseases where herbal medicine is most frequently used. The low prevalence of drug-induced liver injury (DILI) gives rise to the need for large-scale patient studies. We assessed the prevalence of liver injury of 6,894 musculoskeletal disease inpatients taking herbal medicine.
详细描述
Herb-induced liver injury is an important issue in musculoskeletal diseases where herbal medicine is most frequently used. The low prevalence of drug-induced liver injury (DILI) gives rise to the need for large-scale patient studies. The objective of this study is to report on the incidence of liver injury from herbal medicine in musculoskeletal disease patients as large-scale studies are scarce.
Of 32,675 inpatients taking herbal medicine at 7 locations of a Korean medicine hospital between 2005 and 2013, we screened for liver injury in 6,894 patients with liver function tests (LFTs) at admission and discharge. LFTs included t-bilirubin, AST, ALT, and ALP. We assessed for risk factors for liver injury at discharge.
Participants received the most frequently used complementary and alternative medicine treatment contents (herbal medicine, acupuncture, pharmacopuncture, bee venom pharmacopuncture, and Chuna manipulation) administered to musculoskeletal disease patients at this hospital.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients admitted for at least one day who took herbal medicine and at least 2 LFTs during admittance.
排除标准
- 未提供
结局指标
主要结局
Aspartate aminotransferase (AST)
时间窗: Change from baseline (admission) in liver function test up to discharge (average 4 wks)
Participants were followed for the duration of hospital stay, an average of 4 weeks.
Alanine aminotransferase (ALT)
时间窗: Change from baseline (admission) in liver function test up to discharge (average 4 wks)
Participants were followed for the duration of hospital stay, an average of 4 weeks.
Alkaline phosphatase (ALP)
时间窗: Change from baseline (admission) in liver function test up to discharge (average 4 wks)
Participants were followed for the duration of hospital stay, an average of 4 weeks.
Total bilirubin (TB)
时间窗: Change from baseline (admission) in liver function test up to discharge (average 4 wks)
Participants were followed for the duration of hospital stay, an average of 4 weeks.
次要结局
未报告次要终点