MEG in Parkinson¡¯s disease patients with DBS
Recruiting
- Conditions
- Parkinson's disease, Deep Brain Stimulation
- Registration Number
- NL-OMON19892
- Lead Sponsor
- VU medical center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Having undergone STN-DBS placement for PD six months or longer before MEG registrations;
-Age ¡Ý 18 years;
Exclusion Criteria
-Hoehn and Yahr stage higher than 3, as determined in the DBS ON- (but medication OFF-)state.
-Anatomical deformities that prevent the subject from undergoing an MEG registration in supine position (i.e. thoracic kyphosis);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Stimulation site-specific neurophysiological measures, as obtained by MEG recordings, and differences in the exact locations and structural connections of each contact point, as obtained by brain imaging.<br /><br>-Correlation of neurophysiological- and structural data to clinical measures of non-motor symptoms (both pre- and post-DBS), obtained in the context of standard clinical care and clinical studies.
- Secondary Outcome Measures
Name Time Method MDS-UPDRS III-ratings are scored on a regular basis as part of clinical care and can be correlated to the functional and structural networks as well.