Proactive versus reactive inhibition in ADHD: Genetics, Neurobiology and pharmacology
Completed
- Conditions
- aandachtstekortstoornisADHD10009841
- Registration Number
- NL-OMON41454
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
Children diagnosed with ADHD according to DSM IV criteria
Age between 8-16
Willing to discontinue methylphenidate 48 hours before testing
IQ above 75
Exclusion Criteria
History of or present neurological disorder
One or more of the following comorbid disorders are diagnosed: generalized anxiety disorder, depression, tics, psychosis or autism
IQ below 75
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcomes of this study are<br /><br>(1) Stop-associated ERP measures at baseline (N1 and P3) (objective 1.1)<br /><br>(2) Stop-associated fMRI measures at baseline (activitity in IFG an SFG)<br /><br>(objective 1.2)<br /><br>(3) DAT1 and COMT genotype (objective 1.3)</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary outcomes of this study are<br /><br>(1) Coherence of brain activity from EEG (objective 2.1)<br /><br>(2) Connectivity between IFG and SFG from RS-MRI (objective 2.2)</p><br>