Transcranial Magnetic Stimulation and Anti-epileptic Effect: Optimization and Evaluation With Electrophysiology.

Not Applicable

Completed

• Conditions: Refractory Frontal Lobe Epilepsy

• Registration Number: NCT00382707
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Epileptic disease is characterised by enhanced brain excitability. Low frequency repetitive transcranial magnetic stimulation (rTMS) can be an effective treatment for refractory frontal epilepsy. Thought, physiological mechanisms of its effectivity are still unknown. It is yet possible to evaluate cortical excitability and inhibition with TMS-coupled electromyography before and after rTMS sessions ; this could provide clues for basic mechanisms of rTMS effects on the epileptic brain. We assume that rTMS decrease brain excitability by improving brain inhibition. Such an information could help for treating patients with both pharmacological and non-pharmacological methods.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-05
• Study First Submitted: 2006-09-28
• Study First Submitted QC: 2006-09-28
• Study First Posted: 2006-09-29
• Status Verified: 2011-08
• Study Completion: 2011-08
• Last Update Submitted: 2011-08-29
• Last Update Posted: 2011-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Cryptogenic frontal lobe epilepsy
• Normal cerebral MRI

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Electrophysiological parameters for cortical excitability measured just before and after rTMS, 4 hours later and 24 hours later.

Secondary Outcome Measures

Name	Time	Method
Clinical efficacity on seizure intensity and frequency.

Trial Locations

Locations (2)

Département de Neurologie - Hôpital Civil; 🇫🇷 Strasbourg, France

Institut de Physique Biologique; 🇫🇷 Strasbourg, France