NCT01585376已完成不适用
Study Recurrency Testing of Mutations Identified in WGS of Pediatric Rhabdomyosarcoma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 主要终点
- Frequency of particular genetic lesions
研究概览
简要总结
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and find biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
PURPOSE: This research trial studies genes in samples from younger patients with rhabdomyosarcoma.
详细描述
OBJECTIVES:
- To obtain a larger cohort of rhabdomyosarcoma samples (alveolar and embryonal) to establish a more accurate estimate of the frequency of particular genetic lesions.
- To provide the statistical power to establish an unambiguous connection between focal genetic lesions, histological subtype, and outcome for patients with rhabdomyosarcoma.
OUTLINE: DNA samples are analyzed in solid and liquid phase for exons of all genes mutated from previous discovery. DNA is then eluted and sequenced by illumina platform.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Frequency of particular genetic lesions
Identification of mutations that occur in at least 5% of rhabdomyosarcomas as a whole
次要结局
未报告次要终点
研究者
相似试验
已完成
不适用
Studying Biomarkers in Samples From Patients With Recurrent or Metastatic Head and Neck Cancer Treated on E1302 TrialHead and Neck CancerNCT01619618Eastern Cooperative Oncology Group183
已完成
不适用
Biomarkers in Blood Samples From Patients With Refractory Non-Small Cell Lung Cancer Previously Treated With Sorafenib TosylateLung CancerNCT01124669ECOG-ACRIN Cancer Research Group80
已完成
不适用
Biomarkers in Blood and Bone Marrow Samples From Patients With Acute Lymphoblastic LeukemiaLeukemiaNCT01284010Alliance for Clinical Trials in Oncology200
Unknown
不适用
Study of DNA Mutations in Predicting the Effect of External-Beam Radiation Therapy in Patients With Early Breast Cancer, Localized Prostate Cancer, or Gynecological CancerEndometrial CancerFallopian Tube CancerPrimary Peritoneal Cavity CancerBreast CancerProstate CancerOvarian CancerCervical CancerVaginal CancerSarcomaVulvar CancerNCT00601406The Christie NHS Foundation Trust2,200
已完成
不适用
Trastuzumab in Treating Women With Metastatic Breast CancerBreast CancerNCT00896376Centre Antoine Lacassagne49