Genome-wide Association Study to Predict Treatment Response for Chemotherapy in Esophageal Squamous Cell Carcinoma
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Biomarkers predictive
研究概览
简要总结
To explore biomarkers predictive of clinical response to Taxane/5-FU/platinum based chemotherapy in esophageal squamous cell carcinoma. To identify negative predictive markers to 5-FU/platinum/Taxane. To elucidate signal transduction pathway attributable to 5-FU/platinum/Taxane resistance. To analyze correlation between the quantity of circulating tumor cells and circulating endothelial cell precursors and treatment response to Taxane/5-FU/platinum based chemotherapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histological confirmed esophageal squamous cell carcinoma
- •Patients treated with Taxane or 5-FU or platinum based chemotherapy.
- •provision of a signed written informed consent.
排除标准
- •patients not signed written informed consent.
- •patient unacceptable for study in the judgement of the investigator.
结局指标
主要结局
Biomarkers predictive
时间窗: 24months
Biomarkers predictive of clinical response to Taxane or 5-fluorouracil or platinum based chemotherapy.
次要结局
未报告次要终点
研究者
Jeeyun Lee
Professor of Medicine, Sungkyunkwan University School of Medicine, Department of Hematology and Oncology
Samsung Medical Center