Stability of Driving Pressure Changes During "Best Positive End Expiratory Pressure (PEEP)" Trial
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 50
- 主要终点
- Stability of change in Driving Pressure after PEEP manipulation
研究概览
简要总结
The goal of this study is to better understand in changes in lung compliance as indicated by driving pressure (a non-invasive marker) following changes in positive end expiratory pressure (PEEP; a standard of care ventilator parameter).
The main question it aims to answer is: The time to stability of driving pressure after a change in PEEP is made Type of study: observational study participant population/health conditions
Participants will undergo a "best PEEP trial" which is a standard intensive care intervention for patients undergoing invasive mechanical ventilation. This involves changing the patient's PEEP and looking for response in driving pressure. This will be done in a more protocolized format and data will be collected.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients >18 years of age
- •Undergoing intubation and mechanical ventilation in Medical Intensive Care Unit (MICU) or Medical Critical Care Unit (MCCU) at the University of Alabama Birmingham.
排除标准
- •Age <18 years of age
- •Intensive Care Unit (ICU) team declines participation
- •Unstable oxygenation (requiring 100% FiO2 to maintain saturations greater than 90% oxygen saturation following initial PEEP titration by primary team)
- •Hemodynamic instability: vasopressor requirement of >0.3 mcg/kg/min of norepinephrine or equivalent
- •Pneumomediastinum
- •Pneumothorax without chest tube
- •Previous enrolled in trial
- •Need for immediate travel out of ICU following intubation for procedures, tests
结局指标
主要结局
Stability of change in Driving Pressure after PEEP manipulation
时间窗: 10 minutes total
Our study attempts to find the time point when driving pressure reaches stability. The primary outcome will be the first time point (3 breaths, 30 seconds, 1 minute, 3 minutes, 5 minutes, 10 minutes) where driving pressure is not statistically different from the baseline measurement.
次要结局
未报告次要终点
研究者
Ryan L. Goetz
Pulmonary and Critical Care Medicine Fellow
University of Alabama at Birmingham