NCT02627664已完成不适用
Prospective Study of Dysarthria, Swallowing Disorders and Respiratory in Parkinson's Disease
University Hospital, Lille1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2011年3月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- dysarthria severity assessed by the BECD scale
研究概览
简要总结
The investigators prospectively enrolled 64 early PD patients (less than 3 years after the first symptom) in order to prospectively assess the natural history of non-dopaminergic symptoms.
详细描述
Patients were evaluated at baseline and after 2 years in off drug condition. Clinical, psychological, neuropsychological evaluations, functional respiratory evaluation, swallowing video fluoroscopy, dysarthria, gait and axial disorders.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •idiopathic parkinson's disease
排除标准
- •severe axial gait disorders
- •respiratory or ENT pathology
- •Pregnancy
结局指标
主要结局
dysarthria severity assessed by the BECD scale
时间窗: 2 years
BECD (French battery of clinical evaluation of the dysarthria) is a validated scale for qualitative assessment of dysarthria severity in neurological disorders, especially PD
次要结局
- gait axial function (freezing)(2 years)
- Genetic Polymorphisme(2 years)
- respiratory insufficiency detection(2 years)
- swallowing function(2 years)
- Mattis scale(2 years)
- LARS scale(2 years)
- MADRS scale(2 years)
- PAS scale(2 years)
- MoCA(2 years)
研究者
研究点 (1)
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