NCT02047422
Withdrawn
Not Applicable
A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)
ConditionsCongestive Heart Failure
Overview
- Phase
- Not Applicable
- Intervention
- Furosemide
- Conditions
- Congestive Heart Failure
- Sponsor
- Yonsei University
- Primary Endpoint
- urine output change
- Status
- Withdrawn
- Last Updated
- 9 years ago
Overview
Brief Summary
To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients
Investigators
Eligibility Criteria
Inclusion Criteria
- •dyspnea at rest or minimal activity
- •tachypnea (respiratory rate \> 20/min) or rales or pulmonary edema on chest X-ray
Exclusion Criteria
- •hospitalization for acute heart failure decompensation
- •cardiogenic shock (Systolic Blood Pressure \< 80mmHg)
- •Need or plan for renal replacement therapy (dialysis, kidney transplant)
- •serum creatine level \> 2.5mg/dl
- •serum potassium (K+) \> 5.5mg/dl
- •Age \> 80 years old or poor compliance patients
- •allergy, adverse drug reaction, hypersensitivity to any kinds of diuretics
- •life expectancy \< 6 months (e.g. metastatic malignancy, liver cirrhosis)
- •pregnancy or women at age of childbearing potential
Arms & Interventions
Add furosemide/no spironolactone
Intervention: Furosemide
Add metolazone/no spironolactone
Intervention: metolazone
Add furosemid/spironolactone
Intervention: furosemid/spironolactone
Add metolazone/spironolactone
Intervention: metolazone/spironolactone
Outcomes
Primary Outcomes
urine output change
Time Frame: from admission to Hospital Day (HOD)#4
efficacy of diuretics add-on therapy, urine output change
Secondary Outcomes
- serum creatinine change(from admission to HOD#4)
Similar Trials
Withdrawn
Not Applicable
A Prospective, Single-center, Open-label, Pilot Study to Compare the Effectiveness and Safety of Diuretics Add-On Strategy in Chronic Heart Failure Patients (DIOS 1)Congestive Heart FailureNCT01817803Yonsei University
Withdrawn
Phase 4
Polydiuretic Therapy for Heart Failure With Preserved Ejection Fraction and Diabetes MellitusHF - Heart FailureDiabetes MellitusNCT04697485Northwestern University
Completed
Phase 4
Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium AssessmentAcute Heart FailureDiuretics Drug ReactionsNCT05411991Vrije Universiteit Brussel107
Unknown
Phase 4
Evaluating Iron Protein Succinylate Oral Solution in Treating Chronic Heart Failure and Iron DeficiencyChronic Heart FailureIron-deficiencyNCT03344523Lee's Pharmaceutical Limited600
Completed
Phase 4
The Heart Failure Diuresis Efficacy Comparison (DEA-HF) StudyChronic Heart FailureDiuretics Drug ReactionsCongestive Heart FailureNCT05904808Rambam Health Care Campus42