IRCT20211206053304N1
Completed
Phase 1
Initial evaluation of the therapeutic efficacy of 177Lu-FAPI in patients with various end-stage metastatic cancers resistant to standard therapies
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Iran University of Medical Sciences
- Enrollment
- 10
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •the patient should be able to understand and sign off the informed consent.
- •The patient should be able to understand and follow the treatment protocol.
- •Patients should be older than 18\.
- •The patients life expectancy should be over 6 months.
- •patients should show no response to the standard treatment.
- •The 68Ga\-FAPI PET scan or 99mTc\-FAPI SPECT scan should show 3 times more uptake of radiopharmaceutical in tumor to liver of the patients.
- •the patient with progressive disease should be included.
Exclusion Criteria
- •The patients who have received therapeutic radiopharmaceuticals like, 223Ra, 188Re, 186Re, 153Sm during last 6 months.
- •The patients are under systemic therapies like chemotherapy, immunotherapy, or biological treatment for cancer.
- •The patients who have been under any research treatment during 28 days before entrance in this study.
- •The patients who have shown any known allergy to the therapeutic radiopharmaceuticals.
- •The patients who have congestive heart failure.
Outcomes
Primary Outcomes
Not specified
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