Efficacy of Panchatikta Ghruta Guggulu in the Management of Osteoarthritis in Postmenopausal Women -A Randomized controlled Trial

Osteoarthritis is chronic degenerative disorder of multifactorial etiology characterized by the loss of articular cartilage. Menopause has a multitude of effects that affect knee OA, including hormonal shifts, loss of bone mineral density, muscle loss and tendon strength and this common musculoskeletal condition particularly afflicts women in menopause. India is expected to be the chronic disease capital with 60 million people with arthritis by 2025, and prevalence is about 22% to 39%, globally affecting 18% 0f woman over the age of 60.It appears that osteoarthritis in men and women may have different pathogenesis mechanism. Experimental and clinical studies strongly support a link between the increased state of proinflammatory cytokine activity and postmenopausal bone lossThere are studies showing that postmenopausal women have elevated serum levels of proinflammatory cytokines, especially IL-6 and TNF-α.alliative management for Knee Osteoarthritis include NSAIDs and Opioids as mainstays of pharmacotherapy, even Knee Replacement is another option in managing Osteoarthritis. Etoricoxib  seem to be the most effective oral NSAIDs for pain and function in patients with osteoarthritis.But still there are some limitations with adverse effects furthermore; there are no proven disease-modifying therapies for osteoarthritis. Thus, Preventive measures previously addressed need to be reaffirmed throughout the world so that we will effectively reduce the future burden and disability of OAWith this background here is an attempt made to find out the role of ayurveda formulation in management of  osteoarthritis in postmenopausal woman. So the herbomineral compound Panchatikta gruta Gugguluformulation explained in the classics for the treatment of sandhigata vata (osteoarthritis) has been selected for the present study.Hence, the current research has been planned to evaluate the efficacy of Panchatikta Ghruta Guggulu  in the management of osteoarthritis in post menopausal woman through assessing changes in pain, inflammation,  joint mobility, bone metabolism and  quality of life