Effect of a Fluoride Varnish on the Prevention of Dental Caries in permanent teeth:randomized clinical study of 18 months

Not Applicable

• Conditions: non-cavitated enamel carious lesions (white spot lesions) in permanent teeth in children; C07.793.720.210; M01.060.406

• Registration Number: RBR-5vwj4y
• Lead Sponsor: niversidade de São Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-10-18
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Signature of parents or guardians, the Informed consent. Present active white spot lesions (scale 1 Nyvad et al., 2003) on smooth surfaces of at least two teeth in the initial clinical examination.

Exclusion Criteria

users of orthodontic appliances; That participated in another clinical trial within 3 months prior to the selection or subjected to professional fluoride application in the last 6 months; treatment with antibiotics or some other type of medicine (with chronic diseases);with periodontal disease.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1) prevention of cavitated carious lesions evaluated by the DMFT index after 18 months of intervention;<br>2) reversal or progression of enamel lesions previously active non-cavitated present on smooth surfaces evaluated using the Nyvad index after 18 months of intervention;<br>3) reversal or progression of enamel lesions previously active non-cavitated present on smooth surfaces assessed by the change in fluorescence and area of lesions using QLF after 18 months of intervention.

Secondary Outcome Measures

Name	Time	Method
2) reversal or progression of enamel lesions previously active non-cavitated present on smooth surfaces evaluated using the Nyvad index after 1, 6 and 12 months of intervention;<br>3) reversal or progression of enamel lesions previously active non-cavitated present on smooth surfaces assessed by the change in fluorescence and area of lesions using QLF after 1, 6 and 12 months of intervention.